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Is Entyvio safer than Remicade/Humira?

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Crohn's Disease
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Posted 5/7/2016 9:33 AM (GMT -5)
I had an allergic reaction to Remicade. My GI wants me to try Entyvio. I am worried to try anything strong although I know something needs to be done for my crohn's.. Are there any studies that show Entyvio is safer than others? I also heard it's not always effective.
Posted 5/8/2016 8:53 AM (GMT -5)
Entyvio is a more targeted, specific medication than Remicade. Therefore in theory it should be safer with fewer side effects. There have not been any studies head-to-head vs Remicade. Recent safety data shows a low incidence of infection, infusion reactions, and malignancies: http://www.healio.com/gastroenterology/inflammatory-bowel-disease/news/online/%7B3b923e4d-f8f0-48f9-8035-a4c5cbae8de7%7D/entyvio-shows-favorable-long-term-safety-profile-in-ibd-patients

As far as how effective it is, data is still coming in. What is certain, however, is that it takes a lot longer to start working than Remicade does.
Posted 5/8/2016 9:30 PM (GMT -5)
My GI, (who is very knowledgeable about this subject), says that Entyvio is more helpful for inflammation in the colon and less effective in the small bowel. I've also heard that Remicade has more side effects than Entyvio. If you try it I hope it works for you.
Posted 5/10/2016 9:29 AM (GMT -5)
They warn about PML but have never had a case when I started. It's slow to start from what I hear. I have had 3 infusions so far, nothing weird, just cold a lot of the time. At least I don't worry like I did when on Remicade.

T
Better Living Through Chemistry......DuPont's line
Posted 5/10/2016 10:09 AM (GMT -5)
All of them have side effects. My former GI doctor said that even if one case is reported, they have to disclose it as "may be a side effect". So, the side effect could be caused by another drug or totally unrelated, but, if you happen to be on a new drug and develop a new symptom, they report it as a probable side effect. Ever listen to the commercials for Humira or the drugs they give you for depression? Heck, I would rather have depression!!!!

Entyvio was not on the market when I suffered with ulcerative proctitis. Remicade and Humira didn't work for me.
Posted 5/10/2016 10:39 PM (GMT -5)
Thanks for the replies!
Christine, have tou found something that has worked for you? I have bad rectal inflammation and pain and no other symptoms
Posted 5/11/2016 8:42 AM (GMT -5)
As it was explained to me, it is the class of drug that makes them list PML as a possible side effect.

T
Posted 5/11/2016 5:21 PM (GMT -5)
Rose, unfortunately, no. I suffered with ulcerative proctitis for twelve years. I tried 6MP (seven years and did nothing for me), Remicade and Humira. My condition steadily worsened, I became prednisone dependent and it was killing me...literally, killing me. I had a total colectomy with end ileostomy in June of 2010. However, my surgeon left the anus! His reasoning being there are more complications when they remove the anus, but, my disease WAS in the rectum, so, that bit of anus in there (only 2cm) is now diseased. My surgeon retired in 2013 and the anus became ulcerated in 2014. I am now seeing another colorectal surgeon. He has performed two biopsies in the last two years. I have no dysplasia or cancer but he just wants to keep an eye on things. He prescribed cort suppositories, but they irritate more than anything. I was on Cipro for a few weeks last month for an unrelated infection and I think that helped clear up the anus. Keeping my fingers crossed for now. Also, my new surgeon does not recommend surgery to close the anus. He said it would be too much for me to go through. I will be 70 in August, but a healthy 70. Surgery isn't for everyone, but it sure improved my quality of life 100 fold.
Posted 6/24/2019 3:14 PM (GMT -5)
I think all of the “biologics” are pretty similar. Are you guys still on them? I had to quit them all after a really bad infection, a pneumonia that came on quickly. Surgeries and hospital for a month.
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