Horowitz talk only avail 11 hrs

Hey there Rhonda! Thx for this, Im going to watch here in a bit. Dr H is one of my fav's!


xx's-Courtney

I just got up 1/2 hr ago, I missed it, would have loved to listen and take notes.

Sorry MM! I just saw that you already posted notes. I was too busy typing. Thanks for catching that—will change the typo!! Let me know if there are any other typos—a few words I guessed for spelling.

-p

I was not happy to hear the relapse rate is 99% and that he suggests staying on herbs for life!

Read carefully, relapse rate is 99% for short term abx., he didn't mention long term abx which is what most on here are doing.

I don't believe you have to stay on herbs - as in "in treatment"- the rest of your life, but I do believe that we need to use herbs and other means to make sure our bodies are supported and working as well as possible to keep from relapsing or getting reinfected (like I did! UGH! :eyes).

Buhner says that 1,000 mgs of Astragalus will keep the immune system functioning high enough in the right places to keep Lyme at bay - once the infection is treated adequately.

still confused- relapse rate is 99% for everyone or for short term abx and what is short term? Is 6 months short term?

Thanks for the heads up Revive! I watched it last night at 1 in the morning just in case I couldn't catch it today.
My LLMD had me read his book and it helped me start to understand the complexity of what we're going through.

Looks like my LLMD followed his school since my only band at LabCorp was 23 and he said Bingo. You've got it. I had the bull's eye rash about a year and a half before I found him though, so I didn't question his clinical

diagnosis, but I did wonder why only one band showed up. I found it really interesting that he said that the spouses of his patients who had unprotected sex had

tested positive with a high amount of antibodies, but little to no symptoms at all. And a lot of the worst chronic lyme patients barely have any bands showing up. Sounds like sexual transmission is possible, but

gives the immune system a good shot at mounting a defense, almost like a vaccination? I hope that proves to be true, because after 2 years I'm sick of wearing condoms-didn't think I'd have to ever again once I got married-lol

Somewhere along the line, I read Dr. Burrascano's writings that said, if a person doesn't relapse in 3 years after treatment ends, they will never relapse. Of course, this means being on antibiotics for two months after being symptom-free for one month.

Also, as I read "Beating Lyme" by Dr. Lesley Fein, I've found yet another confirmation that the antibody response could be minimal if non-existent in people with long-standing, untreated Lyme - all because the bacteria move into cyst form and/or create biofilms that evade detection by the immune system.

If the immune system isn't aware of the bacteria, it will obviously not be mounting an offense in the form of antibody production.

That is yet another reason why Lyme is a clinical diagnosis.... and testing might *possibly* confirm it.

Turns out they were posted on Nov 4 but the conference was held on May 14, 2014...I thought it was more recent but still pretty recent...

I like how the video's give notes as they play along...

Dr B

/www.youtube.com/watch?v=tMWCvJWVFDs&list=LLMG8afdXqzCo348mADgpB3Q&index=4


Dr H (he touches more on co-infections here)

/www.youtube.com/watch?v=O9a-2Nb2sbk&list=LLMG8afdXqzCo348mADgpB3Q&index=3


-Courtney

I needed a bit of distraction today so I also listened to the interview with Datis Kharrazian regarding autoimmunity and the thyroid… fascinating stuff. I had to take copious notes in order to follow him and then ran out of time before the video access timed out in the last 8 minutes or so - sorry. He also spoke very quickly so I missed some of it.

Datis Kharrazian - Autoimmune Summit Nov 10-28.2014

One of most common autoimmune diseases is autoimmune thyroid:
- but most people who are hypothyroid don't get their antibodies tested because std of care is to identify high TSH and be put on thyroid replacement forever with annual maintenance
- and the assumption that the thyroid will be slowly destroyed over time. - The patient then proceeds thinking they have a metabolic disease, not an autoimmune disease.

Autoimmune disease quite prevalent and it's likely people suffer from (and will continue to acquire) variations of more than one autoimmune problem (celiacs, etc) and that people who suffer from hypothyroidism can't really get thyroid under control without addressing autoimmunity in general.

Many triggers for AI—gluten and other foods are cross-reactive to gluten (rice, corn can also cause gluten response)

Blood sugar stabilities are autoimmune triggers:
- spike of glucose and an insulin surge--IL 6 surge, which stimulates TH17
- drop of glucose

He is going to publish lab research where he has discovered monoclonal antibodies to TSH receptor, TSH, T4, T3 (inaudible) that cross-reacted with 200 different foods:
- 40 foods cause molecular mimicry (cross reactivity) with thyroid—many of the foods are on the paleo diet (raw tuna—not cooked because proteins denature, soy didn't react unless it was processed);
- specific foods cross-react with T3;
- writing manuscript to get it published for "Hashimoto's diet"
- latex was most devastating exposures to Hashimoto's sufferers (food can be prepped with latex—gloves?)
- not everyone with H has reaction, but the tuna antibodies can react w/ T3 due to molecular mimicry.

Has also done with human-derived monoclinic antibody testing with chemicals to determine which chemicals disrupt which part of the thyroid access:
- identifying certain celiac markers vs. (inaudible) 2,3 and 6 and which part of the thyroid they impact
- discovered multiple mechanisms that impact conversion patterns, receptor pathways and the use and availability of hormones and cross-reactivity with immune responses.

Type 1 Diabetes diet also being developed from pancreatic islet cell testing
- found that most foods that cross-react with pancreatic islet cells are also on the "glycemic index" that most people are following

Recently found cross-reactive foods with cerebellum autoimmunity (common in those with Hashimoto's).
- currently doing case studies with his own patients who are having trouble even on a gluten-free diet

Treatment:
Patients who suffer from thyroid disease, untreated high TSH causes accelerated brain degeneration and bone loss and gallstones. Several replacement options that are based on practitioner's preference, not what works uniquely for the patient:
- conventional therapies want levothyroxine, synthetic T4
- alternative therapies want natural or bio-identical like Armour, Naturethroid
- but they are finding that a lot of Hashimoto's patients have such a strong underlying autoimmunity problem that as the thyroid tissues are broken down it causes release of thyroid hormone— that they can't handle the bio-identical source replacement, which has the T3 and the added T3 can cause more problems with anxiety, nervousness, insomnia
- filler issues with the cornstarch in most of the meds, which some people have a gluten cross-reference reaction to
- they checked antibodies to T3, T4 - not TPO but the actual hormone so approach needs to be patient-centric

Brain thyroid AI connection:
- Most of his patients have declining brain health
- 2007 paper published that thyroid antibodies can bind to cerebellar astrocytes (molecular mimicry) and similar findings in his research that the antibodies aren't just attaching to thyroid but also to the brain.
- gluten antibodies also reacting to the cerebellum as well so Hashimoto's patient's brains degenerating - balance issues, vertigo, background movements (flashing) are disturbing, sensitive to light and sound
- these neurological issues get worse and they develop ataxia (can't walk in straight line w/ eyes closed), tremors
- when the brain declines, people will get brain-based fatigue (reading, driving)—not metabolic fatigue, depression
- "Why isn't my Brain Working"—book
- interventions specific to the brain - book explains symptoms for ea mechanism and suggested strategies:
- lack of O2, breach of the blood-brain barrier, neurotransmitter

Once AI is managed, need to approach brain health.

Molecular Mimicry = cross reactivity
- Every protein source has an amino acid sequence and if you have more than 3 amino acid sequences that are identical, then the antibody for one antigen can bind to another.
- So the cerebellum has molecular mimicry with gluten: so when person makes antibodies to gluten, those antibodies have structural similarities to bind to the cerebellum
- when antibodies bind to a tissue, they signal T-cells to destroy it, which you don't want.

Labs to request:
- need to get TPO and thyroid globulin tested (either one that shows up indicates Hashimoto's but you need both tests)
- once AI is confirmed, he investigates what other AI is going on (rare that it is only that tissue)
- multiple tissue AI screening (Cyrex Array 5) - screen for stomach/intestinal/joint/adrenal AI —don't have a deformity yet but are in the stage of AI activity
- the problem today is that no one dx an AI deficiency until the tissue is destroyed (joint deformity to dx RA, MRI show demyleination or plaqing or white lesions to dx MS
- then explore leaky gut, Vit. D deficiencies, etc.

In 8 of 10 patients he sees, there are several AI issues going on—not just Hashimoto's.
- organ-specific AI model currently understood in today's medical practice is outdated—once a person loses self-tolerence, it happens with multiple tissues.
- lupus, etc—outdated.
- loss of self-tolerance, multiple tissues attacked— different stages of silence, then reactivity, then progress into disease
- "predictive antibodies" - GAD antibodies can predict diabetes so H patients antibodies can also inform about other issues.
- he has patients with multiple markers change their diet, lifestyle and can go into remission
- he sometimes sees TPOs increasing when patients get better so you always have to look at antibodies in combination with a T & B cell count and Total White Blood Cell count - many AI patients have very low WBC and very low B cells and aren't well enough to show antibodies
- antibodies themselves don't destroy tissues, antibodies tag tissues and then T cells and K cells then destroy. So antibodies that are very low is almost worse because T and K become so aggressive so sometimes you need to look at the whole immune system holistically to understand what is going on and often total white blood cell was best marker
- yeast and candida connection w/ low WBC count, once candida is treated the cell count goes back up

Loss of chemical tolerance in AI patients:
- latex is major molecular mimicry target for Hashimoto's and under conversion sufferers
- hvy metal content is high but also, immune response to chemical is out of control even when levels are low
- Cyrex Array 11 looks at chemical antibodies (mercury bound to their human albumen to see if there are antibodies against it. When bound to your own tissue, chelation can exacerbate it. Mercury or myelin antibodies present, with chelation the sx can get much worse or grow due to increase exposure.
- should also avoid chelation w/ leaky gut and leaky blood-brain barrier
- you can measure b-b barrier protein antibodies (Cyrex 20)
- with these two areas of leaks and chemical reactivity, makes chelation dangerous
- numerous papers showing that EDTA, DMPS and EMSA (heavy chlators) redistribute metals into the brain and nervous system and some chemicals present don't bind to chelation

Thyroid patients have strong reaction to other chemicals:
- BPA causing AI triggers
- largest BPA exposure is Starbucks lids—heat and acidity from coffee causes chemical reactions in the lid—leaks BPA
- studies done on different drinks in plastic bottles (vary due to acid levels—mountain dew)
- BPA antibodies

Detox
- anything to raise glutathione - biotransformation pathways for Ph 1 and Ph 2 are glutathione based (milk thistle seed, --inaudible—, vit. C, infrared sauna, sweating)
- some people benefit from chelation as long as they have chemical tolerance, blood-brain and intestinal barriers are intact, healthy biotransformation pathways are functioning
- When you look at multi-chemical antibodies at the same time you look at multiple tissue antibodies, like with Cyrex Array 5 - tells you where the AI is going to go
- serious patterns like with brain related AI antibodies and chemical antibodies together because neurons or post mitotic tissues so if you lose these tissues you lose them forever (neurons do not every go through cell division again). So any potential AI to the brain or nervous system - get very very cautious.
- Other tissues have some destruction and then some regeneration through cell division.

1. Diet
2. Gut
3. Detox (latex, BPA and fire retardants)
- "BPA-free" labels are false - use glass and stainless steel only
- fire retardants are sprayed on all furniture sold by manufacturers (both biotransformation process where you metabolize it and also where it binds to your tissues, where it might take several months to process through your body, by touching and off-gassing, replace with organic mattress first

If you are dx w/ H you have to become the expert and take control of your health—healthcare model is very out of date with conventional medicine. Seek alternative care.

There is also one single variable that can impact your immunity, which involves having passion and love in your life, family unit or someone to connect with.
- psychological stress raises interleukin 6 (acts as a pro-inflammatory cytokine), which triggers TH 17, which causes AI flares.
- contrarily, when person is feeling good, someone touches them with compassion and healing emotions, triggers opioid responses, which activate regulatory T-cells, which …

Awesome job with the note P.

I corrected it, 6% of pop in China has Lyme.

Pirouette...where can I listen to this. I would be interested as well.

Thanks.