NEW Published Study - HERBS for Lyme

www.ncbi.nlm.nih.gov/pmc/articles/PMC4738477/

Aims

Little is known about the effects of phytochemicals against Borrelia sp. causing Lyme disease. Current therapeutic approach to this disease is limited to antibiotics. This study examined the anti‐borreliae efficacy of several plant‐derived compounds and micronutrients.

Methods and Results

We tested the efficacy of 15 phytochemicals and micronutrients against three morphological forms of Borrelia burgdoferi and Borrelia garinii: spirochetes, latent rounded forms and biofilm. The results showed that the most potent substances against the spirochete and rounded forms of B. burgdorferi and B. garinii were cis‐2‐decenoic acid, baicalein, monolaurin and kelp (iodine); whereas, only baicalein and monolaurin revealed significant activity against the biofilm. Moreover, cis‐2‐decenoic acid, baicalein and monolaurin did not cause statistically significant cytotoxicity to human HepG2 cells up to 125 μg ml−1 and kelp up to 20 μg ml−1.

Conclusions

The most effective antimicrobial compounds against all morphological forms of the two tested Borrelia sp. were baicalein and monolaurin. This might indicate that the presence of fatty acid and phenyl groups is important for comprehensive antibacterial activity.

Significance and Impact of the Study

This study reveals the potential of phytochemicals as an important tool in the fight against the species of Borrelia causing Lyme disease.

Never heard of those two - Baicalein nor monolaurin, but I would try them - anything to get me to feel loads better!

Did anyone else check out what compounds they were actually testing? It's no wonder they didn't find much efficacy in those things!! Good grief!!

But at least they are trying, right????

I completely agree that at least they are now looking at herbs. At first I got all excited - Finally!! They are looking at herbs, but then I went to go see what herbs they were testing, but their choices were kind of weird I thought.

I'm just listing the compounds and where they come from. Remember "This study examined the anti‐borreliae efficacy of several plant‐derived compounds and micronutrients." They were looking for things that will heal Lyme, and while there are some really good things mentioned, not many of them have been known in the Lyme world to actually heal Borrelia (Lyme). Now, they did test some very interesting things that could easily be of help to many of us, but I just don't see why they chose to test many of these compounds for treating/healing Borrelia.

hydroxytyrosol - Hydroxytyrosol is one of the main phenolic components of olive oil. It is present in the fruit and leaf of the olive (Olea europaea L.).
www.ncbi.nlm.nih.gov/pmc/articles/PMC4428486/

baicalein - Baicalein is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora.
www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:2979

cis‐2‐decenoic acid - Cis-2 decenoic acid disperses biofilm in many strains of microorganisms. However, whether C2DA inhibits bacterial growth or has potential to boost the actions of antibiotics is unknown.
www.ncbi.nlm.nih.gov/pubmed/22585351

morin - Morin , a member of flavonols, is an important bioactive compound by interacting with nucleic acids, enzymes and protein. In this study, we found that morin (30 mg/kg body weight) by oral administration offers protection against hyperammonemia by means of reducing blood ammonia, oxidative stress and enhancing antioxidant status in ammonium chloride-induced (100 mg/kg body weight; i.p) hyperammonemic rats.

oenin - an anthocyanin pigment occurring in the skin of the blue grape and forming a dark red or reddish brown crystalline chloride.
www.merriam-webster.com/dictionary/oenin

vitamin D3

vitamin C

rosmarinic acid - Rosmarinic acid is a plant-based compound found in a wide variety of spices, but most well known for being the active ingredient in Rosemary and Perilla Oil. It displays general anti-oxidant and anti-inflammatory effects, and may protect against various forms of cancers.
/examine.com/supplements/rosmarinic-acid/

kaempferol - Kaempferol is a polyphenol antioxidant found in fruits and vegetables. and this - Epidemiological studies have shown an inverse relationship between kaempferol intake and cancer. Kaempferol may help by augmenting the body’s antioxidant defence against free radicals, which promote the development of cancer.
www.sciencedirect.com/science/article/pii/S0308814612019176

Piceatannol - is a resveratrol analogue with antioxidant, anticancer and anti-inflammatory activities.
Piceatannol has been shown to inhibit NF-κB and JAK-1, two key players in the immune response.
www.invivogen.com/piceatannol

rottlerin (this is a hard one to find something on it that's not super technical) An protein kinase inhibitor derived from the kamala tree
www.yourdictionary.com/rottlerin#xGTxXdXpMefALfSQ.99

Luteolin - an important flavone, which is found in several plant products, including broccoli, pepper, thyme, and celery. Numerous studies have shown that luteolin possesses beneficial neuroprotective effects both in vitro and in vivo.
www.raysahelian.com/luteolin.html

fisetin - Several studies have demonstrated the effects of fisetin against numerous diseases. It is reported to have neurotrophic, anticarcinogenic, anti-inflammatory, and other health beneficial effects.
www.ncbi.nlm.nih.gov/pmc/articles/PMC3689181/

organic kelp with standardized iodine content

monolaurin (Lauricidin®)

Notice there are no strong bactericidal herbs listed? As I said, they do list some things that may be very helpful to us, but none that are bacterialcidal.

One of the compounds they tested actually LOWERS immune function - Piceatannol