In general lumbrokinase (which I believe is buluoke) is the strongest protease. But that doesn't necessarily mean it is the best. I would use the serrapeptase first and so long as you don't have a massive herx work your way into the buluoke.

I'm also taking boluoke. Not many people take it, either cause they can't handle it or it's too expensive. I was wondering what dosage you take. My LLMD recommended one in the morning and one before bed on an empty stomach. However, I find that I either fall asleep before taking it in the evening, or I'm trying to make it last since it's so expensive.

Its great that you feel so much better on it. I'm still looking for that something that helps me turn that oh-so-elusive corner.

Right now I am only taking one Boluoke in the morning. I am also taking the following:

Minocycline 100mg - 2 x day on Sun, Tues, Thrus, Sat
Naltrexone & Azithromycin - 1 x day on Mon, Wed, Thurs
BLT™ Antimicrobial Support - 1 x day full dropper
Transfer Factor LymPlus™ - 2 x day
Jarrow Formulas Saccharomyces Boulardii + MOS - 1 x day
Master Supplements THERALAC - 1 x day
Low dose naltrexone
High grade fish oil
DHEA
Thermotabs Salt Supplement Buffered Tablets (for POTS)
Vit C & Glutathione IVs (up to just recently)

Almost all the above made me feel very icky when introduced but I muscled through it some how. I had bad gut flora too so even the probiotics made me feel icky for a time. The BLT made me feel really bad so I increases real gradual by a drop at a time over 40 days. The Transfer Factor made me feel like I had a fever or localized infection (hot skin sensation to touch). The last thing I introduced is the Bouloke which made me feel really crappy again. After 4 weeks.....This is the best I felt in a long time. I am herxing (or reacting) more from the Bouloke & BLT than the antibiotics now. I am still having slight flareups all day long but the are subsiding. Hopefully, the above may give you some more things to think about. The "Lymecoaster" is a wicked ride. Good Luck in getting it to stop!

Ps. I am also following a very healthy diet and drinkng Kombucha gingerade to help calm my stomach.

Post Edited (DebraB) : 3/30/2015 5:37:12 PM (GMT-6)

Something important to consider when taking systemic enzymes that lyse biofilms is the liberation of pathogens en masse from the reservoir of biofilms when the dam is breached. It is prudent to have a competent practitioner who can be available as some of what people are thinking is a Herxheimer reaction could actually be an increase in the number of liberated pathogens, setting out to start their own biofilm communities. Whatever is your most effective modality of dealing with pathogens, whether it is olive leaf extract/oil of oregano/organic coconut oil/TOA free cat's claw, or cefuroxime/azithromycin/flagyl/rifampin/doxycycline before embarking on biofilm busting it is prudent to have a strategy in place to determine whether suffering is the result of die off and a Herx or if it is an increased pathogen load from dissolving the protective layer around these organisms and liberating them to travel throughout your body, resulting in a super infection. Borrelia spp. conquers and eludes the immune system in some people as it seems to nail the beat cops of the white blood cells, the natural killer CD57 lymphocytes. These lymphocytes sound an alert that activates the rest of the immune system and Borrelia spp. wipes out these lymphocytes so the immune system is unaware of the invaders and does not proceed to make IgM and IgH antibodies which is one reason the ELISA and Western Blot tests have SO many false negatives. Being indirect tests that detect whether the immune system has mounted a response by assaying for antibodies, if the body is unaware of an invader because of a lack of nk CD57 lymphs to sound the alarm, someone extremely ill can be told to seek psychiatric help when an infection of Lyme and coinfectors rages unabated. My personal count has not been out of the teens for over a decade and while my synovial fluid tests antibody positive for several of the organisms that infect us, blood does not contain sufficient quantities of IgG, IgH and IgM subclass III antibodies to register positive on either the ELISA or the WB, although my synovial fluid is STRONGLY positive. Just please be careful when embarking on a program of any of the kinases (lumbro/natto) and serrapeptase and have treatment at your fingertips should you grow very ill when taking these and other biofilm busters like EDTA. Not a doc but have a first rate molecular biology education and have researched this disease exhaustively for 13 years. As a sidenote, lumbrokinase is a fibrinolytic enzyme which means it breaks down fibrinogen, which is a clotting protein that many of us have in excess. It is important that your practitioner knows you are starting this therapy, even though supposedly it does not affect coumadin, Warfarin or your INR. These are just cautionary notes in hopes they may help. Love and blessings to all of you, Ed S.

You can add stevian and xylitol to your arsenal of biofilm breaker. A friend of mine are herxing crazy on 6 drops stevia. He has been doing the other enzymes for some months before that.

How long have you been using the Lumbrokinase? Do be careful, as lymeedbalto pointed out - you will be releasing all of the pathogens in those biofilms when the biofilms are destroyed/opened.

I was using a biofilm buster and wasn't prepared for everything that was released, and had to stop the biofilm buster as well as treatments, when I couldn't get the herxing under control. Just a 'friendly reminder'.

Good!! Do let us know how you are doing and if you have any questions!

I also Take Doctors Best serrapeptase, and occasionally rotate with lumbrokinase.


I found this a few years ago and saved it. Author unknown

"Protomyxzoa is a prolific biofilm producer, in fact ...myxzoa means "slime producing" so lumbrokinase is a necessary treatment component. According to David Berg from AZ Coagulation Consultants and former director of Esoterix lab, tests of biofilm busting properties of the various enzymes show serrapeptase reduces biofilm communities by 70%, nattokinase by 75% and lumbro by 95%."

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