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MTHFR treatment

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Posted 2/14/2017 4:34 PM (GMT -5)
Stupid question time.

How is MTHFR treated? Supplements?

If this is the case, why is it important to know if you have it?

If you're on the proper supplements, wouldn't that correct the problem or as much of it that is correctible?

I know, I think too much 🤔
Posted 2/14/2017 4:46 PM (GMT -5)
Not a stupid question...

I remember asking this over a year ago....why not just take the methylated B's no matter if we have it or not...but i was told not to.

But, I have always taken Methyl B12 - long before lyme hit me, and had no issues...so I continue to take it.
I also bought the Swanson Active B Complex - it has the methylated form of some of the B's.

But I stopped taking it because i haven't had the MTHFR genetic test done.
Posted 2/14/2017 4:58 PM (GMT -5)
My llmd put me on methylBs. I did have a Genova test done that showed some b deficiencies and a "need for methylation" part of the test. But it's not a gene test thing. Do you think that this would mean the same for supplementing?
Posted 2/14/2017 5:07 PM (GMT -5)
btw - it wasn't my LLMD that told me not to take them...it was members on this forum...

I don't know what the Genova test is...and how reliable it is for showing whether you need to supplement with methylated B's.

I do know I have read on here a few times - some people who didn't have the genetic testing done...and do take the Methylated B's.
Posted 2/14/2017 8:38 PM (GMT -5)
Some docs don't place a lot of belief into work MTHFR. They believe it gets way too much hype in treating patients. But here is what Dr. Axe says:

/draxe.com/mthfr-mutation/
Posted 2/14/2017 8:54 PM (GMT -5)
Hard to know what to think😒
Posted 2/14/2017 9:36 PM (GMT -5)
Traveler always says about the detoxing problem with that gene is she just hunts around and adds more detoxing methods until she finds the ones that work.

Sounds like a good plan to me.
Posted 2/15/2017 10:38 AM (GMT -5)
I had this test done a couple of months ago and there was a single mutation C6771. I gave up trying to discuss with this doctor (who took 2 weeks to return 3 messages), but my research indicated a single mutation wasn't an issue. Anyone know anything about this?
Posted 2/15/2017 10:43 AM (GMT -5)
Some people have high levels of B-12 already, or high (enough) levels of folate to not need it. Too much of those things will also cause issues - so it's always best to be tested.

Kat, here is an article from a site that I keep hearing over and over again that it's the best on the web for these issues: mthfr.net/mthfr-c677t-mutation-basic-protocol/2012/02/24/
Posted 2/15/2017 11:51 AM (GMT -5)
I've had my dna run through 23andme.com and I've also uploaded it to Livewello.com, which does a standard variance report. I also have the hetero mutation on C677T, but under methylation Livewello lists 99 other snps that are also related to methylation. There seems to be a lot of focus on the C677T and A1298C, but I'm sure the other snps and/or combination of heterozygous or homozygous snps must have some effect on our methylation.

When I started feeling ill, one of my symptoms was insomnia, which I had never suffered from before. After I started taking a low dose (400 mcg) of 5-methytetrahydrofolate, I started sleeping well again. If I took 2 of them per day...I felt very edgy so I believe we have to be careful about overmethylating as well.

It's going to be an amazing day for humankind when they actually determine how our individual snp mutations and combination of snp mutations affect each of us differently and are able to help heal us from disease and illness with that knowledge. What researchers have learned about genetics; especially in the last 10 years is fascinating.

(Is there a way I can attach a screen shot of part of my methylation variance report? It looks like I can only do it if it's on a website?)
Posted 2/15/2017 11:59 AM (GMT -5)
Vanessa - you have to use a 3rd party photo hosting site - like photobucket, tinypic and others - and get a link to post here.

And thank you for using the word overmethylating!!! In my brain fogged haze this morning, I couldn't come up with that word. Here is a good article explaining overmethylation: mthfr.net/overmethylation-and-undermethylation-case-study/2012/06/27/
Posted 2/15/2017 12:04 PM (GMT -5)
Omgosh great article! Time to quit worrying so much
Posted 2/15/2017 12:23 PM (GMT -5)
Also on B-12, I often test over the top of the range, but I recently had my Vit B12 Binding Capacity, Unsat (Transcobalamin) run and it was very low at 317 (range of 650-1340). My understanding is that the Binding Capacity is reflective of the ability of B12 to be utilized properly. So although my B12 is high...it could mean it's just floating around my blood showing as high. They call it the intrinsic factor. It's all very overwhelming and I know just enough to make me dangerous so everyone should do their own research. I've found that most doctors don't even know what this test is. I requested it and my doctor and a neurologist I saw at Stanford told me my B12 was low and I needed to take more. Really? They see B12 and have a knee jerk reaction to the result instead of actually reading and/or researching what that test is for.
Posted 2/15/2017 12:53 PM (GMT -5)
PK,

Great question. I have this single gene mutation too and find healing/detoxing hard.

I have been taking methyl B12 since way before Lyme and I take MTHR supplements. I'm fine on both and my B12methyl levels are fine now.

I herx on ALA and gluthione so that is something else.

Trav - thanks for another great link.

This is one big mysterious puzzle.

PK, hope you are feeling better.
Posted 2/15/2017 1:00 PM (GMT -5)
Yes...excellent article! Thank you, Traveler! The folate I take is combined with some niacin and a few other things I can't recall right off hand.
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