Diflucan - with or without food

I have never taken these types of drugs. So all I did was google and it says either is fine. With or without food.

/www.drugs.com/cdi/diflucan.html

Diflucan makes me feel slightly off so I usually take it with a light snack.

Take it without food.

"In fasted normal volunteers, administration of a single oral 400 mg dose of DIFLUCAN (fluconazole) leads to a mean Cmax of 6.72 µg/mL (range: 4.12 to 8.08 µg/mL) and after single oral doses of 50–400 mg, fluconazole plasma concentrations and AUC (area under the plasma concentration-time curve) are dose proportional."
/dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f694c617-3383-416c-91b6-b94fda371204&type=display

So ... it is dose proportional, this means 200mg dose on empty stomach should give u 3.36 ug/mL maximum plasma concentration (Cmax).

The Borrelia persisters MIC for fluconazole is 0.48–0.96, See Table 2 in this study
www.mdpi.com/2079-6382/4/3/397/htm

So congrats, you are well in range for bactericidal activity against borrelia persisters, since fluconazole has a half life of 30hours this should actually give you a nice hefty killing time while the drug is above the MIC level.

What's even better is fluconazole penetrates the BBB almost unhinged, so who knows, maybe this will give u a nice brain herx

So are you still sure you are "on an antibiotic break" ? )

But make sure to watch your liver, fluconazole is highly liver toxic.

"The Cmax and AUC data from a food-effect study involving administration of DIFLUCAN (fluconazole) tablets to healthy volunteers under fasting conditions and with a high-fat meal indicated that exposure to the drug is not affected by food. Therefore, DIFLUCAN may be taken without regard to meals."

so it does not matter with or without food. same article as the one i pasted above.

Nothing yet - but it's Day 1

I'm going to take it a few days

maybe it was

Loutucky said...
I took Diflucan two days a week for a year and always took it with my meals. I don't believe my stomach would have tolerated it by itself.

This is kind of funny but my dog has a systemic yeast infection right now and I am giving him Diflucan for 14 days. I always give it with his meals.

Wow you took for a year. That's hardcore. I heard diflucan is really strong.

I took it for like 10 days and then my LLMD wouldn't give me any more and I did Nystatin the rest of the way.

Loutucky - A year break? did you think you were healed and now have relapsed?

How are you doing with the Babs treatment?

Loutucky said...
Girlie, I am on day 45 of babs treatment and only 26 days of one malarone pill twice a day. I am also taking azithromycin and artemisia. My doctor wants me to add in two more malarone pills for a total of 4 a day and Ceftin for lyme. Not now, no way.

I have had about four good days. I am herxing awful with every babs symptom and ones I have never had. Detox really is not helping much. I wish I had known babs was a player five years ago. Tremendous suffering right now.

Sorry to hear about the brutal herxing. Hopefully it subsides soon.

It would probably be a good idea to increase the dosage as you can tolerate it (but ya don't push yourself too much)

The recommended dosage of Atovaquone for Babesia is 750mg twice a day (BID), for a minimum of 5 months. Some doctors recommend dosing even higher.

This recommendation is for the liquid form (Mepron), which is absorbed twice as well as the solid Malarone.

Currently you're on 250mg BID of the less readily absorbed Malarone.

You're definitely doing the right thing starting slow, but your doctor is right in wanting to increase the dosage. Even at 4 tablets per day of Malarone, you're still under what a full Babesia dose should probably be.

Also, can't remember if this has been gone over, but make sure you're taking the pills with lots of fat... 30 - 50g with each dose. If you're not taking the fat with the medication, you're not absorbing much of it at all.

Mustard Seed, thank you for the encouragement. I am taking it slow so I don't have to stop completely for a break.

My insurance would pay nothing for Mepron/Atovaquone. Just could not pay $1250 every 30 days. I am taking at least 30 mg of fat each Malarone dose.

Thank you again for the information!

itsnotjustlyme said...
Be careful with Diflucan.

Unless you have clear problems with yeast, why take Diflucan? There are enough people who cannot get rid of yeast due to taking a round too many of Diflucan.

Be careful with drugs.

Thing is - the list of Candida - is very long - and it shares some symptoms with Lyme and co's.

I don't have any intestinal issues...no diarrhea...no bloating...my tongue isn't white...

I do have some problems with phlegm in my throat...but I've had this off and on for awhile now - pre diagnosis.
Probably acid reflux.

I've decided I'm only taking it for two days...so I'm done now.

I know one Dr. who gives it to patients a few times a week while on antibiotics...but not daily.