May have found a way to disable and treat Lyme neurotoxin - Part 2

Lapis,

Have you decided to cycle the protocol or at least the huperzine A?

I'm at the two week mark and thinking about stopping for a week and cycling every 2 weeks.

I'm confused by the cycling of Huperzine A. The half life is 12 hours. So in 24 hours it is out of a person's system, so I don't quite understand cycling it.

dacarte3 said...
I'm confused by the cycling of Huperzine A. The half life is 12 hours. So in 24 hours it is out of a person's system, so I don't quite understand cycling it.

theoretically supressing acetylcholinesterase for long periods could have negative consequences.

there are 2 parts to the protocol - stimulating acetylcholine, and supressing acetylcholinesterase (the enzyme that breaks acetylcholine down)

HPZ + EGCG is the part of the protocola that suppresses acetylcholinesterase, and so should potentially be taken a break from

alpha GPC, phosphatidylserine, ACL carnitine, and DHA just help to create acetylcholine, and are less likely to have negative consequences with long term use.

also it takes about 48 hrs for the acetylcholinesterase inhibitory properties of the HPZ to be cleared from the system.

Post Edited (Lapis_29) : 11/4/2017 7:42:56 PM (GMT-6)

Lapis_29 said...

dacarte3 said...
I'm confused by the cycling of Huperzine A. The half life is 12 hours. So in 24 hours it is out of a person's system, so I don't quite understand cycling it.

theoretically supressing acetylcholinesterase for long periods could have negative consequences.

there are 2 parts to the protocol - stimulating acetylcholine, and supressing acetylcholinesterase (the enzyme that breaks acetylcholine down)

HPZ + EGCG is the part of the protocola that suppresses acetylcholinesterase, and so should potentially be taken a break from

alpha GPC, phosphatidylserine, ACL carnitine, and DHA just help to create acetylcholine, and are less likely to have negative consequences with long term use.

also it takes about 48 hrs for the acetylcholinesterase inhibitory properties of the HPZ to be cleared from the system.

Interesting. So I'll pulse the hpz and EGCG, take it every other day. And I'll take choline daily.

Because of Lyme, I still think us lymies should take it a bit more frequently than someone without lyme.

Thanks again.

I am extremely confused in researching Choline. I was about to add some to my vitamin order and I came across this which states that people who eat meat and dairy have an unfavorable microbiome in the gut in which Choline intake will lead to production of TMAO, thereby increasing risks of prostate cancer and heart disease.

The following is both scary and fascinating research (well worth the 9minute investment in time):

Carnitine, Choline, Cancer, & Cholesterol: The TMAO Connection
Michael Greger M.D. FACLM April 26th, 2013 Volume 13
/nutritionfacts.org/video/carnitine-choline-cancer-and-cholesterol-the-tmao-connection/

Is this total BS like the "Cholesterol is bad for you" BS or is there some validity to this because I consume meat and eggs and have a microbiome that is customized as a result of dietary habits?

I am totally fine with an I dont know answer over speculation as everyone cant know everything.

I ask because I am convinced that I may have created a perfect storm which caused my testicular cancer back in early 2014 as I was doing large amounts of L-Arganine daily as part of a ketogenic diet as well as using Androgel testosterone hormone replacement therapy which brought my T levels from 200 to 650.

There was 4 months of episodes of short lived sharp pain as a warning before developing lumps and much pain almost overnight. I almost always felt the pain after a warm shower which is when I applied the Androgel. This type of cancer is very rare at then age of 47.

I dont think either by itself can cause cancer but having a latent virus in the herpes family and carrying a fungal infection left untreated for a decade (only found out later on my own because I had dangerously ignorant doctors) combined with overriding my body's defensive hormone down regulation led to the development of cancer within less than 6 months of treatment.

I used to think it was due to keeping my cell phone in my front pocket which may have been a tipping point trigger at best but now I believe it was the aforementioned. Lesson learned, HRT can be deadly under certain conditions.

Therefore I feel I have a legitimate concern. I am definately not trying to throw a wrench into anyone's use of Choline.

ChickenArise said...
I am extremely confused in researching Choline. I was about to add some to my vitamin order and I came across this which states that people who eat meat and dairy have an unfavorable microbiome in the gut in which Choline intake will lead to production of TMAO, thereby increasing risks of prostate cancer and heart disease.

The following is both scary and fascinating research (well worth the 9minute investment in time):

Carnitine, Choline, Cancer, & Cholesterol: The TMAO Connection
Michael Greger M.D. FACLM April 26th, 2013 Volume 13
/nutritionfacts.org/video/carnitine-choline-cancer-and-cholesterol-the-tmao-connection/

Is this total BS like the "Cholesterol is bad for you" BS or is there some validity to this because I consume meat and eggs and have a microbiome that is customized as a result of dietary habits?

I

there could be risks, sure. There is risks for EVERYTHING you put in your body. everything. The quesiton is do the rewards out weight the risks? in this case it is an easy 'yes' for me.

however if you are worried about TMOA there are options.

first what does TMOA do?

Somebody said...

TMAO alters cholesterol metabolism in the intestines, in the liver, and in artery wall. In the presence of TMAO, there is increased deposition of cholesterol in, and decreased removal of cholesterol from, peripheral cells such as those in the artery wall

there is an easy solution to this, the Pauling cardio protocol of Vit C + lysine is designed to solve this exact problem. I already follow this protocol because it builds collagen, which lyme patients need.

http://www.paulingtherapy.com/

secondly you can remodel your gut micriobiota to stop the process of creating TMOA with resveratrol.

Prostate issues come from elevated cadmium levels. That is another whole can of worms.

One Month Review (Neuro-lyme/symptoms):

1. Muscle Weakness - Gone.

2. Muscle wasting - halted

3. Muscle building - re-introduced exercise. Muscle strengthening and growth occurring. However there isn't any clear "new" muscle being built, just strengthening and growth of existing muscle. But only re-introduced exercises a few ago, so even if brand new muscle were to be built it would still take a lot more time. Muscles growth happening quicker due to "muscle memory" (I use to work out a lot, the muscle cells retain "memory").

4. Muscle twitching - 90% gone (this symptom use to be frequently throughout the day, daily).

5. Off balance, wonky and wobbly legs - 95% gone (very rarely happens and when it does only for a few minutes)

6. Head fog - 90% gone (even during a lot of mental exertion the head fog stays at bay)

7. numbness and tingling (hands and lower arm) - for me this only happens while sleeping. In the last 3 weeks since my last update this has only happened two out of the 21 nights. This symptom use to happen every night when I went to sleep or even took a nap during the day.

I'm on multiple Buhner protocols, all the necessary supplements, and did a collective 12-14 weeks of ABX since July.

So it could be a lot of different things making all these symptoms improve, HOWEVER I don't believe it's a coincidence that they didn't improve or didn't make a great leap in improvement until this protocol.

I don't think that timing is simply a coincidence.

A reminder of my Neuro lyme/CNS protocol:

1. Alpha GPC Choline
2. EGCG
3. Huperzine A
4. Fish oil

Girlie said...
dacarte - that is a lot of progress...you must be very happy!!!

- one month? wow.

Hope it continues for you.

Well I've been treating Lyme holistically since July. So in totality almost 5 months but yeah. Thank you.

But it's important to stress again to those reading this that this protocol is a symptom relieving protocol. Please still treat with herbs, abx, probiotics, multi vitamins, diet, etc.

Ok so I have to say something.

I've been drinking energy drinks to stay awake while battling Lyme (I know, not good but sometimes you have little choice).

One specific energy drink seems to help much more than the other ones.

I never understood why. So I looked at the difference the other day.

The only difference was the energy drink that worked way better had Taurine in it.

I've been reading these threads and did some research myself.

Then I found this:

Taurine also increases levels of the neurotransmitter acetylcholine levels and helps to regulate the nervous system.
/www.worldhealth.net/news/taurine/

I really think you're on to something here. I'm going to do more research.

Post Edited (LymeSick 🌟) : 11/19/2017 7:42:29 AM (GMT-7)

wow dacarte3! thats awesome! so glad to hear thing are improving and the protocol likely helped. great news~!

yes, lymesick, I do believe this protocol works, wish more ppl would try it so we have more data. the science is pretty sound, but we need more real world experiences.

LymeSick 🌟 said...
I think I'm going to try Alpha GPC + Uridine, will report with findings if I go through with it.

okay, but thats not really the protocol. you really should add EGCG + huperzine A, otherwise its not really doing much as far as acetylcholine levels go