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doxy stopped working

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Posted 9/25/2018 6:57 AM (GMT -5)
i was bit by a tick watched the rash grow huge over 3 weeks before i realized a had a real problem.got on standard doxy for 3 weeks. coming off i felt bad, weird symptoms very nervy and a host of others that appeared just as the abx should have cleared my system. i went back on dox at double the dose for few weeks , always feeling great on the dox.
i tried to stop again but symptoms returned. so back on dox with a strategy to fight "persisters" with other methods while i hold down the infection with dox. but after a week the dox stopped working and was getting symptoms even on 400 a day.
from what i read lyme does not develop resistance but instead goes into slow growing persister mode in the presence of abx or other unfriendly conditions.
if this is the case why did the dox stop holding symptoms at bay?
Posted 9/25/2018 8:00 AM (GMT -5)
Its a complex disease. You most likely have co-infections like Bart and Babs that has to be treated with other meds. Doxy alone is not enough and most likely puts lyme in dormant cyst mode. You should also take a cyst buster like Flagyl or TindaMax.

Normal MDs don't have a clue. You should see a Lyme Literate Specialist.
Posted 9/25/2018 9:14 AM (GMT -5)
Hey Paisan, welcome to the forum.

You have been mis-informed. Bacteria does become resistant to Doxy. A good case for this is the young people who take Doxy for acne. It works great for a while but after some time it losses it effect and the acne comes back.

You may want to switch over to Minocycline. It works when Doxy doesn't and they both target Lyme equally well.
Posted 9/25/2018 10:32 AM (GMT -5)
thank you for your replys, i think co infection is a possibility. im leaning towards bart as i didnt have any fever that is common with babes.
healing98 im aware of some bacterial resistance to doxy but lyme has not been shown to develop it, its defense is slow growing persister cells.
tickbite im resistent to taking flaygl and the other anti parasitic's they are harsh drugs. i have made lipo garlic and oregeno EO and am taking it sublingualy. the garlic EO is truly evil crap ,fight evil with evil.

it is a very strange space to be in with all the potential infections from a tick bite and almost no reliable testing for if you have it or if you have cleared it. totally in the dark throwing everything at the wall to see what sticks.
good luck to all of you and god bless
Posted 9/25/2018 3:10 PM (GMT -5)
according to sapi doxy makes 200% more round forms of borrelia
/www.ncbi.nlm.nih.gov/pmc/articles/PMC3132871/
Posted 9/25/2018 3:21 PM (GMT -5)
Agree that doxy can become resistant and much more is needed.
Posted 9/25/2018 3:23 PM (GMT -5)

paisan said...
i was bit by a tick watched the rash grow huge over 3 weeks before i realized a had a real problem.got on standard doxy for 3 weeks. coming off i felt bad, weird symptoms very nervy and a host of others that appeared just as the abx should have cleared my system. i went back on dox at double the dose for few weeks , always feeling great on the dox.
i tried to stop again but symptoms returned. so back on dox with a strategy to fight "persisters" with other methods while i hold down the infection with dox. but after a week the dox stopped working and was getting symptoms even on 400 a day.
from what i read lyme does not develop resistance but instead goes into slow growing persister mode in the presence of abx or other unfriendly conditions.
if this is the case why did the dox stop holding symptoms at bay?

Welcome to our community, paisan.


The standard dose for Lyme is 200 mg twice daily. And it should be taken until symptom free for 4 weeks with a minimum of 6 weeks.
If you were taking half that dose...that could explain why it didn't work. Also, you stopped too soon...unfortunately.
In early cases, (acute infections like yours (3 weeks) - doxy is often enough....but non lyme literate Docs generally treat with half dosage and not long enough.

i urge you to find a LLMD asap and get back on treatment.
Posted 9/25/2018 4:36 PM (GMT -5)
besides minocycline, ask your doctor for amoxicillin (if you don't have allergies to penicillin, it is good and goes through the blood brain barrier) 500mg 3x or 2x a day
when it wears off go back to doxy, it'll "work" again
doxy needs to be 200mg per dosage to get through the blood brain barrier
co-infections can harbor the lyme spirochete so when they die off,they can release more spirochete or "overload" your system. You could be making progress and not know it (but again maybe not)
your LLMD or LLND will be very experienced in these regards and know within 5 minutes what is going on, these are just some of the factors that I know about that they will consider, my perspective is just treating myself. 1 year on amoxicillin, it comes and goes in its effectiveness. Penicillin IV is what I am on now.

it is theoritically impossible for lyme to build resistance to antibiotics. it only has 148 genes. what it can do, is change its form, which is just as effective as a defense as building a resistence, BUT it cannot stay in these alternative form for long duration of times (10 months, etc). this is what everyone is eluding to when they are telling you it can't be bacteria resistence. it is unfortunate that we have to figure these things out on ourself, sometimes with intuition, and make broad misunderstandings, and our medical community cannot effectively understand and implement the treatment. keep going it is working. trust your LLMD/LLND
Posted 9/25/2018 4:51 PM (GMT -5)
Amoxy should be dosed minimum of 1000 mg 3X daily. It has a low-half life of 1 hour.

In fact Dr. B. says that sometimes 6000 mg daily is needed.

To combat resistance, this is why more than one antibiotic is used when treating chronic lyme.
Short-Term treatment for acute cases - one antibiotic is usually prescribed.
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