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Deplin Vs L-methyfolate BPD

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Posted 9/9/2019 1:54 PM (GMT -5)
Hello, last winter I was told by my LLMD that I have a double MTHFR mutation and was advised to take 5 L-methylfolate 1,700mcg by Klaire labs. I have been taking this supplement for about 6 months now and really do not notice any difference. Lately I have been dealing with some boderline personality disorder issues and came across a review for the prescription form of L-methylfolate which is Deplin on drugs.com, the revirew read"Deplin has given me my life back. It has enabled me to gain control of my emotional roller coaster and my anger outbursts. I was lucky that my therapist recommended me to be tested for MTHFR after my results came back she gave me Deplin and the next day I woke up a new person. My husband and family are amazed and I'm now capable of being the wife and mother that I want to be. I am so happy and so amazed, I feel WHOLE again" kinda sounds too good to be true but does anyone know if Deplin is any better than the over the counter L-methylfolate that I am taking? Thank you for your help!

Post Edited (CalmLittleBuddha) : 9/9/2019 1:08:09 PM (GMT-6)

Posted 9/9/2019 4:51 PM (GMT -5)
I’m wondering if it’s the dosage?

Are the two brands the same?

Edit - online the Deplin shows 7.5 or 15 mg - are you taking that much?

The other one is 1700 MCG
I believe that is 1.7 mg
Posted 9/9/2019 5:00 PM (GMT -5)
Hi girlie, The brand that I am taking and brought directly from my LLMD is called Klaire labs, the bottle reads 1,700 mcg, 425%. When I mentioned the dose to my neurologist she said that she wasn't to familiar with the supplement but it sounded like a pretty high dose. Thanks for your reply.
Posted 9/9/2019 6:46 PM (GMT -5)
Okay that’s was all a review on the Deplin...I thought you had switched ...
You’re still on the one from your dr?

No matter what - you are taking a very low dose of the b12 compared to what the person who wrote the review was taking.

Have you tested your blood since you’ve been taking the supplement?
Maybe u have very low levels

Or - your b12 is good and no extra is needed. And it’s not causing your issues.
I’ve not found that supplementing b12 makes a difference for me.
Posted 9/9/2019 8:33 PM (GMT -5)
Yes, I am still on the OTC supplement that my LLMD told me to take, I was wondering if Deplin would help me more than the Klaire Labs one. My vitamin B12 levels were last tested in May and the results came back as 376 which my primary Doctor said was good. Thanks again for the help
Posted 9/9/2019 8:37 PM (GMT -5)
Deplin is an extremely high dose, I feel like it's a little too high. But I'm interested if anyone's tried it. A psych recommended it once. I just hate taking so many pills.
Posted 9/9/2019 9:01 PM (GMT -5)

CalmLittleBuddha said...
Yes, I am still on the OTC supplement that my LLMD told me to take, I was wondering if Deplin would help me more than the Klaire Labs one. My vitamin B12 levels were last tested in May and the results came back as 376 which my primary Doctor said was good. Thanks again for the help

It’s hard to say - your symptoms may not be related to b12 deficiency.
There’s been discussions about the blood test only showing what’s circulating around in the blood but possibly not a gauge if it’s being utilized as needed. I don’t know if that is true..
Posted 9/10/2019 8:39 AM (GMT -5)
Jb1994, I don't like taking pills either. That is interesting that your psych recommended it, do you know if you have the MTHFR mutation? Hopfully someone who has tried it will reply. Thanks Girlie for that information,mi didn't know that about the BT only showing what's circulating in the blood, that is interesting!
Posted 9/12/2019 10:04 PM (GMT -5)
I do have a MTHFR mutation, not sure which one. I tried the 5-MTHF supplement and never noticed a difference though.
Posted 9/15/2019 12:56 AM (GMT -5)
I used Deplin 15 when 1st dx single Mthfr.
Deplin was good but there are cheaper alternatives, like Seeking Health products for Mthfr

B12 serum results can be high (mine always >2000 ) but if you’re not converting it to a cellular level that od looking number is useless

Your serum folate can read good too but there are a couple other bloodwork numbers which point to anemia that may indicate you are not converting the b12

Me,among other things , I’m bumping up my “generic” methylfolate back to the deplin 15 dose
Posted 9/15/2019 12:59 AM (GMT -5)
If I’m not mistaken, deplin 15 is a MG dose and you are noting a 1.7 MG dose with the 1700 mcg
I’m struggling today , did I calc this right?

CalmLittleBuddha said...
Hi girlie, The brand that I am taking and brought directly from my LLMD is called Klaire labs, the bottle reads 1,700 mcg, 425%. When I mentioned the dose to my neurologist she said that she wasn't to familiar with the supplement but it sounded like a pretty high dose. Thanks for your reply.

Posted 9/15/2019 1:51 AM (GMT -5)

Village Crazy Lady said...
If I’m not mistaken, deplin 15 is a MG dose and you are noting a 1.7 MG dose with the 1700 mcg
I’m struggling today , did I calc this right?

CalmLittleBuddha said...
Hi girlie, The brand that I am taking and brought directly from my LLMD is called Klaire labs, the bottle reads 1,700 mcg, 425%. When I mentioned the dose to my neurologist she said that she wasn't to familiar with the supplement but it sounded like a pretty high dose. Thanks for your reply.

Yes it’s 1.7 mg - which isn’t a high dose.
Posted 9/15/2019 1:57 AM (GMT -5)
CLBudda
IMO esp with double Mthfr, you need the 15 MG (not a mcg) deplin size dose, there are several affordable sources now to get that methyl folate you must take , and you need to take it forever
Posted 9/15/2019 10:03 AM (GMT -5)
Thank you village crazy lady! I am so impressed by how intelligent everyone on this board is! I am going to look into a higher dose, is there an OTC brand that goes up to 15?!Dose anyone know of any good brands? Thanks again.

Post Edited (CalmLittleBuddha) : 9/15/2019 9:33:04 AM (GMT-6)

Posted 9/15/2019 12:03 PM (GMT -5)
Methylpro offers several strengths and combinations
Seeking Health too
Both can be found on Amazon
And Both are cheaper than Deplin!

VCL
Posted 9/15/2019 1:17 PM (GMT -5)
Thanks so much!
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