Why Does Burbur Stop Working?

I have noticed that Burbur when upon first use is a fantastic way to quickly detox during Herxing since it cleanses the liver and kidneys. However over time the longer it is taken I notice it loses its effectiveness to where during a Herx it has absolutely no effect. I have read where others have had the same issue with Burbur. What causes this and is there anything that can be done to make it effective again? Higher dosages or stop taking it for a while and then start taking it again?

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Yes milk thistle is a good idea. When I first got sick I was diagnosed with chronic fatigue I remember being told that it was a good idea to use different detox strategies along the way. Mixing it up helps helps a lot - because the body has different pathways and mechanisms to detox and it is more effective that way. I wasn't treating the lyme then, I didn't even know about it but I got better just detoxing and milk thistle was the first thing I used and within 2 weeks I picked up a lot. After that I tried different things like chlorella, barley grass, saunas,...it took me more than a decade to get a lyme diagnosis but I was a lot better than I was in the beginning by then, and it was just detoxing.