Rifampin Use

For those who havr used Rifampin for Bartonella, could you please help with a few questions?

1) Is it OK to take at night to try to sleep through side effects?

2) Did you experience leg pain/tightness?

3) Any other tips for successful use?

4) I've noticed the veins in my feet have increased in size a bit since on it - a herx reaction?

Thank you!

Girlie said...
1) Is it OK to take at night to try to sleep through side effects?

If you’re prescribed one daily dose - then I think it would be fine - but ask your Dr.
(I took it twice daily)

2) Did you experience leg pain/tightness?


Tightness- no
some pain - yes - knees
But I was taking another antibiotic with Rifampin (mino)

3) Any other tips for successful use?

Don’t freak out when your pee is a dark orangey red colour.

I took Hawthorne herb daily (still take it a few times a week) for heart/cardiovascular health.


4) I've noticed the veins in my feet have increased in size a bit since on it - a herx reaction?

Not sure

Thank you. I take 600 mg once a day. How much Hawthorne do you take?

in my case Herx from Rifampicin was generally mild but long-lived - rather than lasting only ( added it separately while on doxy and azithro) a few hours after taking it -

so i'm not sure you can time your herx to occur while you are asleep.
but if that works for you great!
i think sleep is more important to recovery in this disease than any abx you can take!

The adrenal problem is not from the die-off. Rifampin upregulates CYP3A4, which destroys cortisol. This causes the adrenals to produce more cortisol.

UAZip05 said...
For those who havr used Rifampin for Bartonella, could you please help with a few questions?

3) Any other tips for successful use?

Thank you!

I have been reading up on treating Bartonella with antibiotics recently
one of the better articles i came across was a video presentation by Dr Burrascano ( of the Lyme guidelines fame )

he favors Clarithromycin and Rifampicin together for Bart
he explains that they have opposite effects on the same liver detoxification pathway CY450

rifampicin speeds it up - lowering the concentrations of other drugs and hormones etc
whereas Clarithromycin ( which he favors for Bart over other macrolides ) slows down the exact same pathway - neutralizing the unwanted effect of Rifampicin.

I get pain in the area of my liver that intensifies with Rifampicin till it interferes with my sleep - so I plan to use this approach when I next do a cycle of abx

as others may have mentioned - single abx monotherapy is not recommended for Bart as it has been shown in lab studies to adapt quickly to single antibiotics like doxy and rifampicin

Garzie said...

UAZip05 said...
For those who havr used Rifampin for Bartonella, could you please help with a few questions?

3) Any other tips for successful use?

Thank you!

I have been reading up on treating Bartonella with antibiotics recently
one of the better articles i came across was a video presentation by Dr Burrascano ( of the Lyme guidelines fame )

he favors Clarithromycin and Rifampicin together for Bart
he explains that they have opposite effects on the same liver detoxification pathway CY450

rifampicin speeds it up - lowering the concentrations of other drugs and hormones etc
whereas Clarithromycin ( which he favors for Bart over other macrolides ) slows down the exact same pathway - neutralizing the unwanted effect of Rifampicin.

I get pain in the area of my liver that intensifies with Rifampicin till it interferes with my sleep - so I plan to use this approach when I next do a cycle of abx

as others may have mentioned - single abx monotherapy is not recommended for Bart as it has been shown in lab studies to adapt quickly to single antibiotics like doxy and rifampicin

Do you mean if you just take Rifampin or just take Doxy? I'm currently taking both.

ChristianWithLyme said...
I'm currently taking 500mg Biaxin 2x day and 300mg Rifampin 2x day. Added one day of Flagyl recently (500mg 2x day).

NAC might affect me (it varies). I thought maybe breaking biofilms but perhaps it's hitting bart or both.

.

yes - i have also read that NAC helps break up biofilms - so it seems it has multiple beneficial effects in Lyme and co
- glutathione precursor
- direct anti-bacterial against some intracellular pathogens
- biofilm disrupting effects

I'm not sure if it is separate to its glutathione boosting effect or via the same mechanism - but i think its a sulfur donor that helps with sulfation detoxification pathways in the liver

UAZip05 said...

Garzie said...
either one on their own is supposed to be problematic as Bart has been shown to adapt to single abx rapidly.
both together is better. both are often used in triple abx combinations also

OK cool thank you, I am on both now

\\\\\\\\\\\\\\\\\\\\\\\\\

All three B’s you should be taking 2 (or more) antibiotics (or one plus an antimalarial for Babesia

H Mommy said...
Girlie, I would love to know who your LLMD is. I remember reading your posts in the past. It sounds like this doctor really know what they’re doing and I’m considering antibiotics again. I don’t know how you could let me know though as we probably can’t give names in here.

You could email me.

I see Dr J in DC

And this one:

https://m.youtube.com/watch?v=wde0l-5ykvi