Thiamine Deficiency and the work of Elliot Overton

I had posted about how I was having great results using a high fat, ketogenic diet in healing my immune/neurological diseases.

But I wanted to speak about another piece of the puzzle that my NP has clued me onto. I had complained on this board multiple times that I had extreme exercise intolerance. My muscles burn as soon as I start working out, to the point where, as an otherwise athletic looking guy, I find it hard to run even a mile, no matter how much training I have. My NP astutely recognized this as lactic acid buildup. In concert w/ my complaints of fibromyalgia and migraines, both which have been linked to acidosis, and some critical risk factors like dysbiosis and high caffine intake, she surmised that a thiamine deficiency could be underpinning my chronic issues going back to my teens, long before any downstream autoimmunity even began. This was very intriguing to me, as I've long complained that there was some breakdown in one of my critical pathways "gumming me up", but I could not figure out what...I assumed it was mercury, for lack of a better enemy.

I never realized how important B1 is. Without it, none of the other b vitamins work properly, and neither does the krebs cycle. A lot of people theorize that metabolic insufficiency is the lynchpin behind all chronic illness. I will not try to explain this guy's work, as I'm just beginning to look into this stuff and try to understand it, but I'd say the video is well worth the time if youre suffering from CFS or neurological issues.

https://www.youtube.com/watch?v=vehsfddg2hu

Right now my plan of attack for immune and nerve rebuilding is a high-fat ketogenic diet, but one of the supplementation changes she's made is high dose bentofiamine and all-thiamine, and ONLY THEN will we add in other b-vitamins and ALA. Will keep people posted on if it helps, so far I'm only up to 500mg. Takes time to ramp it up.

Note: You will also recall that I wrote a post a few months ago about how Alka Selzter Gold ameliorates my symptoms for brief periods. It's very well possible that its leveling out the PH level of my blood when I'm suffering from mild lactic acidosis

Post Edited (dcd2103) : 11/29/2020 12:13:25 PM (GMT-7)

Thank you so much for posting this, I will be looking into this, looking into several books on classic nutrition and reading about Thiamine (B1) and some ties with celiac or gluten issues makes me think that this could explain some of the issues I've recently been through!

I believe I will buy some Thiamine supplements to see how I react to that.

I will report back,


Doors12

Also, in addition to the supplement I mentioned above, there's also Thiamax.

Thiamax
https://www.objectivenutrients.com/products/thiamax

Doors, I'm so happy its helping! I think you can go higher in dosage. I'm really noticing the improvement the past couple weeks now that I'm up to 1500mg bento (goal is to get up to 2000 slowly). Game changer is the right word!

I'm not sure if the heart palps are related to the bento...dont think it should be, but keep me posted on what happens when you take a break. But i do know that bento can keep you up at night if you take it in the evening, take it first thing in the morning w/ breakfast (best absorbed w/ some fat)

I wish others would explore this as well!

If you need a nutritionist, and you can get an appointment, there's no one better than mary...and she works exclusively through telehealth. She's the one who got me onto the bento thing.

https://www.enableyourhealing.com/

Post Edited (dcd2103) : 12/17/2020 6:19:18 AM (GMT-7)

doors12,

Thanks for your nice comments. I'm glad if anything I wrote was helpful. I stand in dcd2103's shadow and try to catch any scraps that fall my way.

Also, I'm delighted to hear of your boost in energy. Now, we just have to get your heart palpitations figured out, so you can get more sleep. Like many of us, I have sleep problems, too.

Anyway, keep on reading, asking questions, and experimenting wisely. Don't stop advocating for yourself, because you deserve to get better!

I wish you many blessings, my friend.

Dude

Thiamine deficiency is one of the issues I found for Lyme patients and it develops over time. The amount of deficiency varies, but the bacteria in the GI tract that make thiamine are not in sufficient numbers to make enough. What ends up happening is that your tryptophan levels fall because it is used up to make niacin. The thiamine deficiency can help suppress this conversion. Some vitamins and minerals are more important than others and a cycling effect occurs IMO. Eating a ketogenic diet increases tryptophan levels which increase the neurotransmitter pathway and the production of serotonin, melatonin, dopamine, and norepinephrine. The problem still remains that the bacteria that make tryptophan are not in sufficient numbers. My belief is that a pathogen(s) create a pH that decreases their ability to thrive.

https://pubmed.ncbi.nlm.nih.gov/25253514/

1)Lactic acid build up is actually quite uncommon, yet its mentioned a lot. There is an accurate blood test for this which Ive had. Its a simple physical procedure with before and after blood draw.The Drs who do this are in specialty children's "muscle disease" hospitals.

2)Thiamin B1 levels can be tested with intracelular testing.

3)On the subject B's, dont forget some odd ball chronically ill people seem to pool B6 in their blood to over range levels, which is not good. Was a post on that last month or so.

Hi there,
Just wanting to know if you ever heard of metabolic or mitochondrial myopathies.
I've had the same symptom of exercise intolerance (inability to go into the anaerobic phase of energy production) with the same kind of lactate build up as a consequence since I was a kid.
The same happens if I eat only meat in one day or if I eat higher fat meals. Another thing that points to defective instructions to make ATP from fats or proteins.
Some people with mitochondrial defects do very well on a high fat diet though - it all depends on where the faulty instruction is.

My neurologist saw my symptoms and that they respond very well to high doses of allithiamine and has me tested for genetic myopathies. The testing is done through the state insurance - this means that my symptoms fit to a T, otherwise you don't get genetic testing for a lifelong of "crazy" varied symptoms and "exercise intolerance".

Let me know if you want to chat up more about this.

Mara

dcd2103 said...
I had posted about how I was having great results using a high fat, ketogenic diet in healing my immune/neurological diseases.

But I wanted to speak about another piece of the puzzle that my NP has clued me onto. I had complained on this board multiple times that I had extreme exercise intolerance. My muscles burn as soon as I start working out, to the point where, as an otherwise athletic looking guy, I find it hard to run even a mile, no matter how much training I have. My NP astutely recognized this as lactic acid buildup. In concert w/ my complaints of fibromyalgia and migraines, both which have been linked to acidosis, and some critical risk factors like dysbiosis and high caffine intake, she surmised that a thiamine deficiency could be underpinning my chronic issues going back to my teens, long before any downstream autoimmunity even began. This was very intriguing to me, as I've long complained that there was some breakdown in one of my critical pathways "gumming me up", but I could not figure out what...I assumed it was mercury, for lack of a better enemy.

I never realized how important B1 is. Without it, none of the other b vitamins work properly, and neither does the krebs cycle. A lot of people theorize that metabolic insufficiency is the lynchpin behind all chronic illness. I will not try to explain this guy's work, as I'm just beginning to look into this stuff and try to understand it, but I'd say the video is well worth the time if youre suffering from CFS or neurological issues.

https://www.youtube.com/watch?v=vehsfddg2hu

Right now my plan of attack for immune and nerve rebuilding is a high-fat ketogenic diet, but one of the supplementation changes she's made is high dose bentofiamine and all-thiamine, and ONLY THEN will we add in other b-vitamins and ALA. Will keep people posted on if it helps, so far I'm only up to 500mg. Takes time to ramp it up.

Note: You will also recall that I wrote a post a few months ago about how Alka Selzter Gold ameliorates my symptoms for brief periods. It's very well possible that its leveling out the PH level of my blood when I'm suffering from mild lactic acidosis