Chronically low white blood count

For the last 2 years, my wbc ranges from 2.5 to 3.1. I looked back through labs to 2013 and it seemed to be always in the mid 3's to sometime. I asked my LLMD about it last appt and he said he didn't know and I should ask my hematologist. I don't seem him until Feb. and it doesn't seem to be worth a phone call.

I have been on maintenance for at least the last 2 years (1 week on - 5-6 off depending how I feel).

Anyone else have this issue. I do remember back when I was on IV LLMD gave something that raised it. I thought it was Leucovorin but looking around on the internet I am not sure that is correct.

Leucovorin is a form of folate or folic acid i think - used to prevent anaemia secondary to folic acid inhibition from the dapsone

Welcome to the forum, trkane

Yes, mine was low. Years after being lyme cured, its boarder line low normal to sometimes under.

WBC count is just an average of other immune cells.

All or some of these might also be low:

-Lymphocytes
-CD57 (another test of averages)
-T cells
-B cells,
-NK cells
-Globulin and total protein (all- immune cells are a form of protein)
-Immunoglobulins like IgG, IgA

Some of the above are still below limits in me, however; I feel fine.

Interesting. Leucovorin is used in anemia to raise RBC.

But my WBC went from a 3.0 to 4.5 last March. Initially I thought it was from keto, but that’s been proven false since I’m back in ketosis for 5m and didn’t rise.

Recently i went back to see what supplements I was on at the time and I was on b12 and seeking health folinic acid, in addition to a bunch of other things, but I had been curious if it was the folinic acid that did it. I recently tried some folinic acid for the last week and no pop yet, but welll see

Girlie,

Your wbc will rise during your 3 off? I have been up to 6 off and definitely tested everywhere in that 6 off with not change.

I am not worried about it but it bugs me that chronic low wbc is associated with infection. I will have to look back and see if my drop in wbc is associated with an increase in the time between my on week.

trkane said...
Girlie,

Your wbc will rise during your 3 off? I have been up to 6 off and definitely tested everywhere in that 6 off with not change.

I am not worried about it but it bugs me that chronic low wbc is associated with infection. I will have to look back and see if my drop in wbc is associated with an increase in the time between my on week.

I have delayed my lab work by a week or two (while off the abx) and the wbc did rise some.

I was on more Doxy than anything else in addition to Biaxin, Ceftin, Flagil, one other not to popular here too- and not mentioned in this thread.

tr - that's interesting - and it could just be a co-incidence but the azole antifungals have been shown to be remarkably effective in treating bartonella in some recent studies - outperforming traditional bartonella drugs like rifampicin

i mention this because many of the people who have low white blood cell counts here seem to have bartonella.

so i guess its possible that the Voriconozole took care of the bartonella and the white cells then came back? just a thought.

study is here is anyone is interested
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc6628006/

there are a lot of azole antifungals that score highly on the list

Results
Activity of top 41 active hits that had good activity against stationary phase B. henselae
Drugs (50 μM) Residual Viable Cell Percentage
Primary Screen b Confirmation Microscopy c
Drug free control 60% 81%
Gentamicin 2% 32%
Azithromycin 17% 42%
Streptomycin 9% 39%
Tetracycline 12% 50%
Rifampin 2% 59%
Doxycycline 11% 60%
Penicillin 13% 60%
Erythromycin 14% 66%
Chloramphenicol 13% 70%
Cefuroxime 21% 73%
Ciprofloxacin 30% 74%
Pyrvinium pamoate 0% d ND e
Amifostine 27% 10%
Daptomycin 7% 21%
Lopinavir/ritonavir 9% 21%
Sulconazole 3% 22%
Econazole 8% 22%
Oxiconazole 3% 24%
Butoconazole 11% 25%
Methylene blue 16% 25%
Clotrimazole 7% 27%
Dibekacin * 9% 28%
Abamectin * 2% 30%
Colistin 4% 30%
Bifonazole 4% 31%
Amikacin 12% 32%
Nitroxoline 6% 33%
Miconazole 8% 35%
Chlorosalicylanilide * 17% 38%
Berberine 8% 39%
Meclocycline * 11% 40%
Nebramycin * 2% 41%
Kanamycin 9% 44%
Dichlorophen * 14% 45%
Verteporfin 0% d 45%
Pentamidine 15% 46%
Cloxyquin * 7% 48%
Aprepitant 0% d 49%
Puromycin * 6% 49%
Amaranth * 3% 50%
Lomerizine * 8% 51%
Carbomycin * 16% 52%
Spiramycin * 14% 53%
Thiethylperazine 4% 55%
Clinafloxacin 11% 56%
Clofoctol 12% 58%
Meclizine 11% 60%
Pazufloxacin * 12% 62%
Nitrofurantoin 16% 63%
Diclazuril * 15% 64%
Olsalazine 18% 64%
Nifuroxazide * 7% 65%