Butyrate - anybody use this?

Just came across this when looking at BodyBio’s TUDCA reviews and saw a reviewer mentioned taking this with TUDCA.

I searched the forum. All but one mention was on the UC forum. The one mention here was Georgia Hunter, who said, “The first step in fixing dysautonomia is to increase butyrate in the colon. If this doesn't happen, I would not know where to start to fix the issues.”
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BodyBio says this about Butyrate:

“Butyrate is produced by your gut microbes and has many important functions within the human body, particularly for digestive health, supporting brain health and protecting against disease*. It's an effective gut health supplement with full body benefits.

Not only is Butyrate critical in repairing the lining of the gut and the health of cells within it—it also supports healthy inflammation response to protect the body from disease while improving immune function*.

Butyrate repairs the damage that pesticides, toxins, processed foods, drugs, etcetera have done to the lining of the gut. Butyrate helps to heal the gut lining and promotes healthy DNA to support genetic function against damage, which may lead to disease*.
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Since most of us have leaky gut or other gut dysfunction, I wonder why I have never heard about this or been told to take it.

i have tried it - i think i had a small benefit - but overall not enough to justify the expense

butyrate is one of the short chain fatty acids made by fermentation in the colon and adsorbed then used systemically as an energy source when your glucose levels are low. it also helps provide fuel and healing to the cells that line the gut and has anti-inflammatory effects. acetate and propionate are the other main ones

when i read up on it i found a healthy person should be making a few grams of each, or something in that region per day.

so you can see how supplementing with a few hundred milligrams per day might have some effect - especially if your levels are very low - but none at all if they are already fine.

its the fibre fermenting bacteria that mainly make these compounds - and it could be argued a much more effective way of achieving higher levels and thereby better gut and brain health would be by nurturing the healthy populations of the organisms that make them in the large bowel - typically with healthy forms of fibre and resistant starch type compounds in the diet. it is this increased production of short chain fatty acids that is indicated as the mechanism by which diets high in these substances is thought to regulate mood, sleep etc - at least that how we are designed to work.

get some high quality ghee. Its very high in butyrate without any of the smelly problems. Plus its delicious. Great for the microbiome and the gut.

Best ghee I ever had

https://www.pureindianfoods.com/