question for Girlie .....

hey Girlie

i remember you posting about your protocol at Dr J's - included the following

"Week 3 or 4 (my choice): Alinia (don't remember the dosage) Monday-Friday"

just curious what Dr J was intending the Alinia for ?

as far as i know there is no hard data as in studies on its use for lyme or bart or babs - but that doesn't mean it isnt useful

do you recall why he was using it ??

many thanks!

yea-ok said...
Alinia tested well during in vitro stationary/persister borrelia study (NTZ=Nitazoxanide), especially note the test tube that had cefuroxime+clarithromycin+nitazoxanide. I think Alinia (Nitazoxanide) has an excellent safety profile?

https://www.researchgate.net/publication/343899842_evaluation_of_disulfiram_drug_combinations_and_identification_of_other_more_effective_combinations_against_stationary_phase_borrelia_burgdorferi

Going by in vitro results, Nitroxoline looked more promising, and it more recently had its own in vitro study for use against Lyme. However, for a US LLMD, Nitroxoline is not approved/available in the US. There is a Russian supplier that supposedly ships 50mg tablets in a 50-pack, but a normal dosage would be at least 400-800mg/day.

Dr Marty Ross is on the fence about Alinia, he only claims it is good for various GI parasites.
https://www.treatlyme.net/guide/alinia-lyme-disease

thanks for the study link Yea-OK - that's very helpful !

i heard Dr S P also believes its active for lyme - but he was on record as saying this was based on unpublished research from someone he knew - so its good to see there is some study evidence now

Thanks Girlie - i know it was a memory tester

the term parasite is rather broad - it really just means any organism that lives off its hosts resources - usually at the hosts expense

but colloquially its often used to describe things like worms, flukes, nematodes etc

for some reason people often refer to babesia and malaria also as a parasite - but really its just a single celled organism - in this case an apicomplexan - which are a diverse group of single celled animals - like protozoa - which infect humans and animals.

it may be that some of the same drugs that are used for the multicellular parasites like worms - can have some activity against apicomplexans like babesia - and so because we use anti-parasitic meds for them - perhaps that's why the name "parasite" has stuck - but they are not really any more parasitic than borrelia or any of the other infections...

so its a bit odd

yea-ok said...
For Babesia, maybe there is a mild effect? A study last year looked at Nitazoxanide and it’s analogues+metabolites, aiming to find new malaria drug candidates because of drug resistance. They also noted NTZ really does have anti-viral activity.

“...(Nitazoxanide)... ... we concluded that the nitro group of 11 would play an important role for its bioactivity against the human malaria parasite.”

(2021) Synthesis And Antiplasmodial Assessment of Nitazoxanide And Analogues As New Antimalarial Candidates

In 2015, this guy claims (without citation) NTZ has activity against Babesia. Read the comments, there is a recent one claiming amateur dark field microscopy analysis showed NTZ is effective for Lyme (Edit, upon watching his YouTube microscopy, I’m not convinced he is looking at spirochetes):
https://www.linkedin.com/pulse/nitazoxanide-known-killer-parasites-borrelia-cysts-booster-ozimek

I found old mentions of Alinia being used by some Lyme doctors before 2009, probably based upon the rumors of unpublished research you mention — I’ve also seen that before, somewhere.

thanks very much for the links - indeed it looks like some mild effect is possible against Babesia ( based on some mild anti-malarial effect )

i agree - i saw the videos by the guy in the linkedin comments - but do not see anything that would correspond to spirochetes in either video. i think the same guy who posted the microscopy videos is in one of the Facebook bartonella groups - he does some good microscopy - but like you - i do not share all of his interpretations.

there is a microscopy thread on here where some papers are discussed showing that "vesicles" and other cellular debris can and do form "string of pearls" and thread like objects - often interpreted as spirochetes by amateur macroscopics in darkfield slides - but the authors demonstrated via PCR that they are of human origin not bacterial or spirochete. many still prefer to believe they are looking at spirochetes - but the evidence was rather compelling

thanks again for sharing the info