SS-31 Peptide (Elamipretide) for Lyme and co-infections / fatigue

Day 6:

- Last days went so well with this experiment that I went from 500mcg to 750mcg today.
- Still had the same 15% increase in energy from baseline, however:
- Energy feels better because at this dose it appears to be more stable throughout the day (this could also be the cumulative effect).
- Noticed a deeper sleep 🤔... It's good to have a deeper sleep, but I hope that the reason isn't that I'm exhausting myself. It doesn't feel like I am, but I'm keeping an eye on it.
- Skin improvements are still going steady

I'm trying to work my way up to 1mg and then reassess if it's worth it to end up at a 2mg dose.
On the peptide communities I've noticed that people roughly do one of these options:

- 500 mcg daily
- 1 mg daily
- 2 mg daily
- 40 mg daily

That last one (40 mg) is due to a study that used this, but I'm not going to go that high myself.

So for me, I'm trying to decide between 1mg and 2mg and then stay on one of those two options.

It's great to see something positive happening for you, Rainy. The pretty consistent pattern of improvement is a good sign. Here's wishing it continues.

I'm on day 4. Started at 100 MCG. Now at 200 MCG. I really like this stuff so far.

A couple add on thoughts.. this has shifted my stack of adaptogen/neurotransmitter like support. In fact all I'm taking in regards to that now is the LDN. I believe this relates to the nature of the peptide to influence the serotonin/dopamine system. Specifically dimethyl tyrosine residues - why this made me get off my 5HTP (when that normally balances out excessive dopamine/epinephrine) and feel like i was throwing myself into serotonin syndrome at 4am is beyond me..

I've also had some major personal IRL changes that have influenced my stress levels for better or worse over the past few weeks. So I'm not 100% it's PURELY the SS-31, but there is correlative data..

It’s really hard to describe and I don’t want to hyper analyze the early days. My experience hasn’t been too far from yours. I will say It’s a very natural well being feeling.

I went up to 300mcg today.

I’ll do a more in depth update around 2 and 4 weeks depending on dosage progress etc..

On a side note I was really intimidated at the thought of injecting myself but found the hurdle super easy to get over.

Oh and I have also read feedback around dosing like you mentioned, but paradoxically I also read an equal amount of like 250mcg made me tired but 1mg etc was a game changer. Which you don’t hear often in this space.

Are you planning to add mots-c at some point?

So after a few days a 500 mcg I discontinued due to unusual headaches and a woozy feeling. I returned to 200 mcg a few days later, had a decent couple days but side effects are present at this dose - being a bit less but unusual headaches and feeling slightly off.

This stuff does knock out a lot of post exertion soreness still which I love. Went paddle boarding yesterday for the first time in 5 years.

A bit uncertain where to go from here..

I did optimistically order another bottle + a blend of mots-c/humanin at 5mg/5mg (it was a great deal for the blend vs buying each of those separate).

I also got my sleep back on a better track.

Was hoping to have something more "positive" to share but wanted to keep it honest.

Thanks for the input rainy! Hope you find a solution to this for yourself too.

I personally am not resonating much with the nutrient theory (outside of a neurotransmitter). There is a loose correlation between stopping the 5-htp and the peptide becoming "less" effective. But I was also having concerns continuing the 5-htp too.

I'm also pondering if some sorta detox is going on neuro wise. Which would explain the below the neck benefits but above the neck "retracements". Chat GPT actually suggested this as a top explanation as I thought it was too out there to post about..

Anyways. Keep me updated

Hope you feel better soon rainy, keep up your Battle. Just know we're there for you

Hey Rainy. Hope you're starting to turn the corner on that!

I'm still working a few different angles with the ss-31 but I feel like I'm chasing my own tail sometimes.

I went back on the 5-htp at my normal dose + gaba (new one for me). This eliminated 85-90% of side effects above the neck (I've also been trying to stay extra hydrated). But I also seem to have lost a lot of the benefit below the neck at the same time and % with the myalgias. And some sleep issues once more after a few days of upping dose of ss-31 (waking up an hour earlier still tired but wanting another hour or two and can't fall back asleep).

I'm wondering if this vial has degraded over the weeks I've had it in the fridge?

I wanted to finish this vial but might start the mots-c and humanin over the next few days to see what that does.

I'll keep things updated as I discover things of value to add.

Hi Loski!

It's nice to hear from you and thank you for the update!

I'm glad you are having moderate success with rotating them! How do you like the humanin by itself? That's one that I haven't tried yet.

I just realized I didn't respond to your previous post. So I wanted to mention that SS-31 won't expire in a few weeks, if its been in the fridge it should be fine. One of my SS-31 bottles is going strong on like 6 weeks now, and I haven't noticed any reduced efficacy.

There was some concern that mots-c degraded fast but a Japanese study confirmed that it didn't either.

Are you taking the SS-31 in the mornings? I forgot. That might help with the sleep issues.

I'm doing well myself, thank you for asking! I'm trying to take SS-31 daily now but sometimes I'm too tired to get that and other chores done.

I have noticed this odd thing where if I start SS-31 after a while of not taking it, then I get tired. But when I continuously take it, then I won't. So that might indicate that its something the body needs to get used to, or something along those lines.

I was reading this review and someone was saying that when you take it for like 2-3 months that eventually the results will be even more significant when you finish a cycle, such as that particular one. It gave me hope that maybe there will be additional benefits in addition to the ones I have now.

Today I came across another interesting compound that appeared to be for sale: SLU-PP-332

It's supposed to give you some of the benefits of exercise without exercising. Which in theory could be helpful for us given that for many of us are unable to do exercise. It kind of reminds me of mots-c in a way, but I haven't tried it yet.

Here's a quick abstract but there are many more articles and studies:

https://www.biorxiv.org/content/10.1101/2022.10.05.510974v1

I also started doing glutathione injection daily and those have also been helpful.

Please keep me posted!

Rainy - are you still taking? If so have you noticed any weight loss?

I’m tolerating 1mg fairly well now.

I’ve been a bit more active and eating a lot (usually am on the thin side) and thought to weigh myself as I had to be at a healthy weight and I was the shocked to see my weight down 10-15lbs. A number doesn’t mean everything but caught me off guard. I’ll also add I don’t feel like I lost weight in any sense either.

Thanks for the Input and update Rainy.

Yes I was still cycling the mots-c/humanin as well. Perhaps I'll drop that for a couple weeks.

Keep in mind glutathione doesn't work for all molds, and if your issue is with the glucoronidation pathway - that and glutathione push and pull on each other a bit. Not saying that's the case, but a lesser talked about angle.

So I'm more or less wrapping up the ss-31 experimentation and plan to use it on my somewhat recently started one day a week gym routine. I had a good leg day today. And not just good relative to the past year, but close to "normal" good - i mentally slowed myself out of caution but was at a 80-85% intensity. I did run out of my vial this morning after injecting and had been doing an injection day of workout and day after. I don't contribute this 100% to the ss-31 (too much going on to ever know what does exactly what) but it is a non-insignificant influence.

I've also started selank via nasal spray within the past week. Maybe that could turn into a new thread.

I also plan to incorporate melanotan 1 as the sun fades on me - as I actually got a healthy tan this summer (my dad won't stop telling me how I no longer look grey). Unsure if this will replicate my theorized A-MSH benefits exactly, melanotan 2 and KPV are also on my radar but for brevity's sake M1 was what I'm gravitating towards.

Several other peptides are now on my radar.

An extra thanks to Rainy for creating this thread and bringing this to my attention