I found this interesting on the Marty Ross site.....

in reference to bartonella treatment

Marty Ross said...
Endothelial Glycocalyx: The endothelial glycocalyx is a crucial, gel-like layer lining blood vessels, vital for vascular health. It regulates permeability, maintains blood flow and blood vessel dilation by producing nitric oxide, and prevents clotting. Bartonella infects blood vessel endothelial cells which may damage the glycocalyx.

diagram of what it looks like in healthy states - here ( blue layer)
VIEW IMAGE

i have not seen it mentioned before - and i think he is probably guessing - or making a logical extension that it could be a key area to help healing from Bartonella - rather than there being any direct scientific evidence of efficacy in bart infections

but i still found it interesting - basically the gel layer keeps substances from directly contacting the endothelial cells themselves - so if thelayer is missing - direct contact between these cells and things in the blood steam like bartonella - or things leaking from the gut etc - would be likely to react with the endothelial cells - causing immune responses and inflammation.

i wondered if this mechanism might be involved in the auto-immunity so common with chronic bartonella infections

edit - i dont think marty ross is practicing any longer - he retired recently i think - and he has his own website - so i dont think there is any issue mentioning his name

He has retired but there are LLMDs that follow his loose protocol. My LLMD is one of them. I pretty much self treat and only use my doc for tests, etc.

Ross isn’t married to one way of doing things which is a plus. I don’t follow his protocols, even though I don’t have issue with them.

Sea vegetables really are wonderful for us, but they're so rarely parts of people's diets! I can't stand the taste, personally, but force myself to eat them anyway, particularly ground up in ramen or other soups, steamed veggies, and sauces. I'm sure it's not enough to provide the levels in the supplement you mentioned, but it's something. My family actually likes the taste and will eat dulse like potato chips.

I started integrating various seaweeds into my diet 15 years ago when I moved into a house with (stable) lead paint and learned that digitata kelp can bind to lead and remove it from the body. It also contains fucoidan, which binds to SARS-SoV-2 molecules in the gut to lighten the viral load, and provides iodine (also kills SARS-CoV-2 and TBD). Good stuff.

A wonderful, sustainable harvester sells bulk seaweeds, if anyone is interested: theseaweedman.com

slightly different i think - i dont think they knew about the Endothelial Glycocalyx when buhner was writing about l-arginine etc

i think arginine works by increasing NO production - which has vasodilatory and also by reducing inflammation in the endothelium and reducing adhesion of platelets to the endothelium - which would otherwise tend to cause inflammation.

however, it could be that the EG is involved in the mechanisms of those somewhere along the line

i seem to remember something about arginine reversing the changes in white blood cells triggered by bart - when taken in high doses - although i have to say i have been taking 4g a day for along time now- several years - and not sure how much help it really is

saraeli said...
A wonderful, sustainable harvester sells bulk seaweeds, if anyone is interested: theseaweedman.com

Sara,
I looked up the site. Sounds interesting, but $50/lb!!! That’s way too much for my pocketbook. Is that pound fresh or dried? One pound would only make one meal, wouldn’t it?

Thx for the info, Sara! I have eaten dried kelp snacks from the grocery store and never had an issue.

for more info on exactly how the endothelium may be getting damaged - i asked google how platelets cause inflammation

Google AI summary said...

Platelets cause inflammation by releasing substances that activate immune cells and destabilize endothelial barriers.
How platelets release substances

Granules
-Platelets store cytokines, chemokines, and adhesion molecules in granules. When platelets are activated, they release these substances into the surrounding area.

Microvesicles
-Platelets release microvesicles that can activate neutrophils and interact with endothelial cells.

Toll-like receptors (TLRs)
-Platelets have TLRs that recognize pathogen-associated molecular patterns (PAMPs) from microbes and inflamed tissues.

How platelets activate immune cells
-Platelet-derived mediators
-Platelets release mediators that attract leukocytes and activate innate and adaptive immune cells.

Platelet-derived HMGB1
-Activated platelets release HMGB1, which increases platelet aggregation and thrombus formation.

How platelets destabilize endothelial barriers

IL-1β
-Activated platelets release IL-1β, which destabilizes endothelial barriers and increases endothelial permeability.

Serotonin
-Activated platelets release serotonin, which destabilizes endothelial barriers.

Yep. Thats the supplement with the seaweed extract in it discussed above.

Have you tried it WBF?

Wonder would chlorella have se same effect, it is seaweed too isnt it..?

Equilib has been my favorite multi because of its CNS support blend. I was looking tonight and Atlantic kelp is listed in there - which reminded me of this post

Just wanted to share