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Interesting new article on the evaluation of currently available antibiotics

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Posted 7/4/2014 5:45 PM (GMT -5)
This is a really good new article on antibiotics and why Lyme disease treatment can become difficult!

http://www.nature.com/emi/journal/v3/n7/full/emi201453a.html

Interesting septra DS has a low MIC! So it was traditionally thought of as a bartonella abx, but also works excellent on Lyme.

No wonder my treatment of minocycline + tinidazole + Plaquenil + septra DS worked so well!

Also it highlights the 2 phases Lyme germs can be on. Log phase which is where they grow rapidly and stationary phase where they are not growing at all. Most abx are only effective during the log phase... But there are options out there now for stationary phase as well!
Posted 7/4/2014 9:24 PM (GMT -5)
www.nature.com/emi/journal/v3/n7/full/emi201453a.html
Posted 7/6/2014 11:32 AM (GMT -5)
Lymepickle, thank you for posting the link to this article.

I am very excited by the research that Dr. Zhang and team from the Johns Hopkins University have done because they have taken antibiotics that are commonly available to all practitioners and tested them against the common strain of Lyme. Even though the research was done in vitro, I think that this is a great start and hope that many other research centers will follow suit so we can determine what are the best available antibiotics out there for Lyme and company, specially in vivo.

As I read the article, I could not help to think of those here who have had little success with treating Lyme with Doxy or Amox. I also thought of those who have plateau in their treatment after a certain period of treatment. Perhaps adding or replacing one of the many antibiotics with one that showed to be effective may turn the tide for us who can't seem to move forward.

Now, imagine if Dr. Zhang was to take his research and add Banderol or Cats Claw to the mix and compare it to these antibacterials. I would pay to see the results. If they showed to be as effective as some antibacterials, that would shoot the use of herbals into the stratosphere versus being ignored by all but a few of the traditional medicine practitioners at this time.

I would like to hear from others in this post as to whether this article will encourage them to try some of the abx that proved to be more effective in treating Lyme.

Post Edited (Healing98) : 7/6/2014 11:41:47 AM (GMT-6)

Posted 7/6/2014 2:48 PM (GMT -5)
Well the new standard for IV therapy for those with later stage Lyme disease will be daptomycin instead of ceftrioxone. That will clean house fast but it doesn't have the best penetration for the brain, but possibly increasing the dose will improve that.

Clofazimine although working very well and easily accumulates in tissues where Lyme can be may prove to work well. Although this drug has nasty chronic skin discoloration side effects.

Cefoperazone is now the best ranking cephalosporin. Also needs to be administered by IV.

Excellent oral therapy will be carbomycin. This is the best macrolide of them all and is easily tolerable.

I'm disappointed they didn't show data for minocycline but I saw data for minocycline in another article testing abx against Lyme and it said MBC is 2-4 ug/ml and the MIC is likely the same as doxy.

Also I love to see Septra DS work so well against Lyme as this drug is probably the easiest antibiotic to tolerate out of all the kinds I have tried. Low MIC value, gets into all tissues including the brain, AND is easy to tolerate. The only issue is some people are allergic. Gets into all tissues, brain, intracellular. And will prevent Lyme from ever growing and getting worse.

I see an excellent treatment option of simply combining septra DS with a 3rd generation oral cephalosporin that penetrates into the brain well like for example omnicef (cefdinir). That is going to be my next therapy. That is if I can get this in Canada! Disappointing how canada has much fewer drug options.

With this data we can probably work easily with just 2 or 3 abx at a time.
Posted 10/30/2014 2:51 PM (GMT -5)
LymePickle - I just found this article and asked you about in a different post. You just told me that taking Bactrim and another abx would make the other abx less effective yet your post above says you would take Bactrim and omnicef. I am taking (without success) ceftin. I have some bactrim as home from an old RX. Should I or shouldn't I add it to my ceftin. Just an FYI, I will definitely be going on IV rocephin around Nov. 8/9 so this would be a one week/ten day plan.
Posted 10/30/2014 7:23 PM (GMT -5)
Well I'm certainly not a Doctor. And you said you had no success with ceftin? Ceftin called by it's generic name cefuroxime generally works quite well… Although some say what works for one person may not work for another person. Maybe you got co-infections creating a good chunk of your symptoms? Or maybe your bacterial load is pretty high and you have to be patient?

I am going to be trying ceftin for the first time on Saturday morning. So we will see how it works for me.

If you keep taking the bactrim in the meantime it will keep the bugs from getting worse until you go on the IV rocephin that is for sure. But ya… according to this article ceftin should work as well as IV rocephin.

It is upto you what to do with your body. Maybe ask your Doctor? You said it is not working for you, but I would say try if you can handle it. What is the dosage? My Doc has me going on 1000 mg twice a day.
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