I would say no. Psyllium husk is the main ingredient in Metamucil - a fiber therapy agent. Psyllium seed husks are the outer coating of the seed found in the psyllium plant, which creates a completely natural form of fiber.
Cholestyramine is a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption.
en.wikipedia.org/wiki/Cholestyramine So they work differently.