I just came across this article about
Oscar Wilde's wife just being "diagnosed" with MS through examination of old letters. Sounds like Lyme to me. They didn't know what it was then, either.
"The letters detail symptoms that progressively robbed her of the ability to walk, riddling her body with pain and leaving her with excruciating headaches and extreme fatigue."
http://www.theguardian.com/culture/2015/jan/02/death-oscar-wilde-wife-solved
Just for fun! (Isn't it sad that this is my idea of "fun"?)