With LD/MSIDS, most here have had so many of the overlapping symptoms of EBV/Mono, FM, MS, CFS, Parkinsons, ALS, right? Neuropathy, stiff neck, intermittent fevers, tremors, extreme fatigue, limbs feeling like cement, extreme muscle or joint pain, etc. Many here have lost limb ability, or came close to losing ability, treatment mercifully helping.
And yes, I, too, have had friends who have had EACH of these "diagnoses", who do NOT want to hear about
LD/MSIDS or any possible tie-in! I have an in-law whose father died of ALS & both daughters with MS. The family lives in a LD concentrated area, the ALS man having retired from the military..No questions asked, just diagnoses accepted.
Another neighbor friend of mine with Fibro (can any folks here sympathize with agonizing body pain?). I have have shared LD, etc info. She & her spouse don't want to even discuss it. Btw, I have used the soft shoe approach in trying to share. Currently, this woman is mad at her doctor who now states he doesn't believe she "even has FM," so she is searching to find another doc who will give her back her title & pain meds.
I have a neighbor friend who this June will be undergoing
open brain surgery for Parkinsons. Previously, I worked with a friend whose mother had Parkinsons, & about
10 yrs ago she underwent this same surgery, with initial success, but then decline. My neighbor's family has made up their mind to have the brain surgery, not wanting to hear about
my previous friend's experience or the similarities to LD symptoms. They do not want to hear that the brain & body is very likely impacted due to vascular blockage--the vermin within forming a plaque not allowing crucial blood to the brain & body.
And although it is a small study not yet getting the acclaim, the Stephen Fry study paper does point a direction that, to me, makes plausible sense! For those who have not taken the time to read it, I am going to cut & paste some of the relative extracts that jump out at me:
"Many previously intractable chronic disorders have been shown to be closely associated with polymicrobial biofilm communities. These microbial communities are characterised by adherent, polysaccharide-secreting communal microorganisms. The communal nature of these organisms and the surrounding biofilm matrix results in significant hurdles for treatment as they promote immune system evasion, antimicrobial treatment resistance, and inherent recalcitrance...In the human arterial system, biofilm bacteria have been documented as contributors to arterial plaque. There are only a handful of protozoal microorganisms reported to have biofilm-forming properties. Among these are Acanthamoeba sp., Trypanosoma brucei, Pneumocystis carinii,..& initial report of protozoan biofilm communities in ALS patients...
Amyotrophic lateral sclerosis
Arguably one of the most studied and most conflicting series of results is that regarding the potential viral
aetiology of ALS. Suspected culprits include ...polioviruses, enteroviruses, herpesviruses (HHV-6, HHV-7, HHV-8 ), echoviruses (ECHO6 and ECHO7), and even human endogenous retroviruses. Bacteria have also been studied, whereby Borrelia burgdorferi (the causative organisms for Lyme disease), Mycoplasma sp., and cyanobacteria have all been considered as potential associated factors. It has been reported, as with multiple sclerosis, that the seasonal emergence of ticks is connected with ALS risk...
Amyotrophic lateral sclerosis
Clinical metagenomics using NGS revealed a detectable population of protozoa...A mixed population of potentially opportunistic bacteria (SSR1300599) and two different types of protozoa were identified (SSR1300602) through NGS and subsequent metagenomic analysis. The primary identified
bacteria were Blastobacter denitrificans (22.6%), Rubrivivax gelatinosus (17.8%), and Streptococcus mitis (7.9%) (Table 2). The primary protozoal contributors were identified as another divergent Perkinsus qugwadi-like species (68.3%) and an Orchomonas sp. (11.6%)
Chronic fatigue syndrome
Chronic fatigue syndrome is closely related to FM and Gulf War Veterans’ Illness by several overlapping clinical features Persistent enteroviruses have been reported in patients with CFS, and there is some symptomology overlap with irritable bowel syndrome [45, 46]. Most recently, 142 patients with CFS and herpesvirus infections were treated with some reported degree of success [47]. A number of studies cite the role of Mycoplasma sp. and Coxiella burnetti in CFS [48-54]. Currently there are few publications regarding a potential role of protozoa in CFS. Infection by intestinal parasite Giardia sp. has also
been correlated with CFS [55, 56]. It has also been considered, based on a case whereby Acanthamoeba sp. was detected in a previously diagnosed CFS patient [57], that features of CFS may be due to an immunocompromised status. It is also of note that CFS patients present with significantly increased antibody titres to various Apicomplexan protozoa, such as Toxoplasma gondii and Sarcocystis
sp. [58]
Fibromyalgia
Bacteria have been studied to some extent, with various Mycoplasma species and viral organisms showing some level of non-trivial prevalence. However, neither significant clinical impact nor adoption of new treatment modalities has resulted from this research [52]. Doxycycline, an adjunctive medication in the treatment of malaria, has been utilised in the treatment of FM patients [53, 59], and this drug has been shown to be effective, although the mechanism was proposed to be due to a global anti-inflammatory effect [60, 61].
In this article we document six examples of biofilm communities: five isolated from peripheral venous system samples from SLE, FM, CFS, MS, and ALS, and a single sample from carotid angioplasty.
All samples have prominent protozoan components...In FM, MS, ALS, and angioplasty debris the identified protozoa are potentially of aquatic origin. Generally, the primary identified protozoa are potentially related to known pathogens of animals, thus raising the possibility of zoonotic infection or transmission. It is possible that these organisms may enter a human host via insect vectors, contaminated water, or contaminated food.
In light of the reported results, clinical observations, and current literature we propose the following scenario in these polymicrobial biofilm infections. An initial insult is the protozoan entry into the bloodstream, probably vector mediated (mosquito, tick, or another arthropod), although parenteral routes are also possible.
An incubation period of days to weeks ensues, and then there is a time of illness with malaise and flulike symptoms. In the majority of affected individuals there is a remission, and some may experience persistent malaise and progressive clinical symptoms. If such a microorganism persists in a biofilm community, it may become protected from immune and inflammatory responses by polysaccharides, nucleic acids, and peptides building the biofilm scaffold.
In periods of emotional stress, illness, trauma, or dietary excess these biofilm communities may resurge and spread as immune surveillance is curtailed. In addition, biofilm can be permanently attached to the vascular wall. Due to quorum sensing and other mechanisms, excessive growth of such a microbial community and parasitic burden is diminished. However, possible cracks in the biofilm could expose the underlying organisms to the immune system, initiating response of the human host. Such disruptions in the biofilm matrix and immune system recognition may be intermittent, which may explain the relapsing and remitting nature of MS.
Based on our results, we hypothesize that biofilmforming protozoa may represent a non-trivial component in human disease and that the human vascular system may be a significant site of colonisation..."
http://www.termedia.pl/Original-paper-Putative-biofilm-forming-organisms-in-the-human-vasculature-expanded-case-reports-and-review-of-the-literature,76,23697,1,1.html
Post Edited (happyjo) : 5/29/2015 10:30:04 AM (GMT-6)