My first thoughts are that he is herxing as well. The herbs being used make it seem that he is being treated for Lyme and Babesia, although as Girlie pointed out, the Japanese Knotweed and Sida Acuta also treat Bartonella. That combined with the Doxy is a pretty heavy hitting combo. If all he is doing for detoxing is the Epsom Salt soaks, he likely needs to really increase what he is doing for detoxing.
Did he have the gene mutation testing done (MTHFR) to see if he has those gene mutations that can make it much more difficult for a person to detox effectively?
There are so many things that he could still do to increase his body's ability to detox. Girlie covered some of them, and pointed you to our "New to Lyme?" thread for more ideas, and here is another link that you can read more about
possible detoxing methods for those of us treating these infections :
www.tiredoflyme.com/detox-methods.html Sleep is a tough one to tackle, as there are so many things that can interfere - pain, hunger, adrenals, hormones, and more. I've tried all kinds of things over the years to try to improve my sleep and from my own experience and that of others, I believe that it usually takes several things to help a person get the rest they need. For me, it's taken melatonin, Lidtke brand tryptophan (the brand makes the difference here), valerian and magnesium - but you will have to experiment a bit to see what will work for your son. Your doctor should help you out with suggestions, but if he doesn't, that's a topic that is brought up a lot on here.