Source: Dr. Paul Duray Research Fellowship Endowment Inc

Newsletter No. 4

(snip)



(1) Borrelia DNA and antibodies to Borrelial proteins found in Lewy Bodies


From the F1000 poster by Alan B. MacDonald, MD, FCAP:


"Diffuse Cortical Lewy Body Dementia (DCLBD) is a neurodegenerative disease of unknown causation. Under the microscope, in the cerebral cortex of the human brain are numerous Lewy Bodies. ...Herein are presented two autopsy cases of DCLBD Dementia in human patients in their seventh decade of life. ...


"Herein we present that the Lewy Bodies in DCLBD are in addition immunoreacitve for Borrelia burgdorferi proteins by Immunohistochemistry (IHC) studies using rabbit antibodies against whole cell lysates of pure cultures of Borrelia burgdorferi
spirochetes...

"Further, we demonstrate the hybridization of DNA probes specific for the DNA of Borrelia burgdorferi, by Fluorescence In Situ DNA Hybridization (FISH) ...


"These two data sets establish that a heretofore un-imagined linkage exists between chronic (Tertiary) neuroborreliosis in the human brain and the development of Diffuse Cortical Lewy body Dementia..."

View full report of these two tragic cases, with micrographs, here:

http://f1000research.com/posters/5-127

Thank you so much for sharing. My dad suffered for several years with Lewy Body dementia until he passed 2 years ago. It is a horrible disease that takes a person to places they can't even imagine. He lived most of his life in the country with woods all around. It is very possible that is what caused his disease.

Just one more reason to seek treatment before it is too late. When I think back I realize he suffered a lot of anxiety starting in his 50's. Makes me wonder if it was caused by this as well.

Thanks again. May help to shed light on this got me and my siblings.