CD-57

The CD 57 is not a good test for anything. No one knows what all happens in the body to create a low CD57 - or a high CD 57. Some that are very debilitated and extremely sick with Lyme can have a very high CD57, and some with hardly any symptoms at all can have very low CD 57 numbers.

What we do believe is that for those that do have a low CD 57, it can be tracked to (hopefully) see improvements as we heal.

/www.researchednutritionals.com/library/lyme/everything-you-wanted-to-know-about-cd57/

All of my doctors track my CD57. Basically it doesn't necessarily indicate Lyme, but it is one of several indicators that can give some insight into how well your immune system is or is not functioning. Some also believe that the CD57 is lowered by other bacteria or viruses that dampen the immune system, for example EBV, mycoplasma.
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A below-normal count has been associated with chronic Lyme disease by the work of Drs. Raphael Stricker and Edward Winger. No one knows for sure why CD57+ NK cells are low in Lyme disease patients, but it is important to note that many disease states that are often confused with chronic Lyme (MS, systemic lupus, rheumatoid arthritis) are not associated with low CD57+ NK counts. The good news is that for most Lyme patients the CD57+ NK level increases as treatment progresses and health is regained.

CD57 markers can also be expressed on other kinds of cells, including T-cells, so it is important to distinguish between CD57+ T-cells and CD57+ NK cells. Clinicians need to be aware that many testing laboratories claiming to perform the CD57 test are actually looking at CD57+ T-cells rather than CD57+ NK cells, which are the cells of interest in chronic Lyme disease.

And what about CD3+? My LLMD says it is connected with viruses in the body. I have both CD57 and CD3+ low.
Never tested C4a, actually never heard of it.