Most of us prefer to not wait until we are herxing to detox - then you are trying to play catch up with the toxins. Detoxing daily is a much better, as it helps keep those toxins lower daily, rather than waiting for them to build up enough for us to be miserable as we try to lower them back down once in a while.
Everyone has a different detox need/tolerance though, so be careful in adding in each method, but find what works best for you. I think it's safe to say that none of us wants to have to do more detoxing than is needed anyway. LOL!
I have not had any of the gene mutation testing done, although I do seem to have the same kind of issues as those that do - so I figured it was best for me to assume that I did and work to get my body to detox much better, which means I do a LOT of detoxing daily.
It took a lot of diet changes as things with my body changed,
I use a foot soak daily,
dry skin brushing,
making sure my bowels moved at least once a day (sorry if it's TMI!)
pushing myself to drink at least 64 ounces of lemon water each and every day,
liver/gall bladder flushes (all natural), as needed,
oil pulling with tea tree oil,
taking activated charcoal, as needed,
Alpha lipoic acid,
Quercetin,
turmeric,
Methyl B-12 and methyl folate,
Dandelion tincture,
red root tincture,
Yogi brand detox tea (original flavor)
(and I know I'm missing other things I do! LOL!)
and keeping the amount of stress in my life at a bare minimum.
I have used apple cider vinegar to help with detoxing as well - it's really good, but started making my stomach issues worse, so I stopped using it daily and only use it occasionally when I know I need a boost in my detoxing for just a day or two.
You can find some really good detoxing suggestions in the "New to Lyme?" thread that sits at the top of the forum. And this is another really good resource for detoxing ideas for Lyme patients:
www.tiredoflyme.com/detox-methods.html But, there is such a thing as over detoxing. This happens when we move more toxins than our body is capable of processing out effectively. Many toxins are stored in our tissues, and by detoxing, we move them to the bloodstream where we can process them out of our bodies through the lymph system, then on to the liver and kidneys as so on. We have to be sure to add in more detoxing routines slowly and carefully, or we will end up herxing just like we had never been detoxing. This article helps to explain that some:
www.tiredoflyme.com/4-reasons-why-you-still-feel-bad-despite-detoxing.html