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Posted 4/5/2017 10:00 PM (GMT -5)
Basically a new LLMD prescribed me rifmapn to try cause he thinks my symptoms point to bartonella.

I've heard mixed reviews about the drug online.

Anyone know what side effects to expect and tips for using the drug?

Thanks
Posted 4/5/2017 10:21 PM (GMT -5)
i took mine before bed. It makes your urine orange/red. I had no noticeable side effects or problems with it.
Posted 4/5/2017 10:22 PM (GMT -5)
Well, you should get orange pee.

It can be hard on the liver. But, for me it wasn't. Get regular liver function testing done.

I took it on an empty stomach and tolerated it well.
Posted 4/5/2017 10:23 PM (GMT -5)
are you taking 300 twice or 600 once daily?

the 600 once daily caused me to herx...after about a year on the 300 mg twice daily dosing.

What are you pairing with it?
Posted 4/5/2017 10:51 PM (GMT -5)
Glad to here about minimal side effects. I'll be sure to test my liver after a couple days on it.

My prescribed dose is 300 twice daily. I'm going to Florida for a week in the sun so the next meds I plan to start once I'm back which include Doxy and tinidazole.

Although my insurance won't cover tinidazole so I'm gonna ask the doctor if he recommends anything else or ordering it overseas.

Post Edited (Xelaetaks) : 4/5/2017 10:02:09 PM (GMT-6)

Posted 4/5/2017 11:01 PM (GMT -5)
I have a love hate with riffy...i love it cuz it works i hate it cuz it works ...
i have been pulsing 600 like girlie ...it burns through meds, cortisol and other abx 2x as fast ..it makes liver work 2x a hard too...support with ala ,glutithione and dandylion and anything else you can get your hands on ...makes me super tired the next day ..try to eat it on empty.lots of fluids etc etc

it is argue that it may or may not pass bbb ...i did have some flushing ,weird hives, and some skin discoloration but ya know " just keep swimming
Posted 4/7/2017 11:25 PM (GMT -5)
Anyone heard about the risk of pancreatic issues from rifmapn?

Apparently there's something to do that. My lipase levels are amlittle elevated lately and I wonder if that might be a reason to be cautious about the drug.

I left a message for my Dr. also to see what he thinks but I'm curious if anyone has heard about this.

Thanks
Posted 4/7/2017 11:32 PM (GMT -5)
I don't think the lipase levels are tested in my monthly blood work.

No, I hadn't heard of it.
Posted 4/8/2017 8:20 AM (GMT -5)
Make sure you keep testing liver every month.

I drink detox tea, take nac, ala, liposomal glutathione and phosphatidylcholine for liver. Many take milk thistle too.

I was fine on 300 mg 1x a day. I am upping to 600 mg after vacation.
Posted 4/8/2017 8:23 AM (GMT -5)

Girlie said...
after about a year on the 300 mg twice daily dosing.

What are you pairing with it?

Were you recently looking into Bactrim because you feel as if you many not get over the hump with Rifampin? Just curious as to how you feel about it overall and what you are discovering in your research of alternatives and or pairing.
Posted 4/8/2017 1:15 PM (GMT -5)

k07 said...
Make sure you keep testing liver every month.

I drink detox tea, take nac, ala, liposomal glutathione and phosphatidylcholine for liver. Many take milk thistle too.

I was fine on 300 mg 1x a day. I am upping to 600 mg after vacation.

I never understood with milk thistle if it's safe to take while drugs are active in your system. I.E. Does it interact with the bodys drug intake or something?

I do plan to take it though. Also my doctor said I could start on 300 mg once a day so I guess I'll try that out and see how it goes.
Posted 4/8/2017 1:24 PM (GMT -5)

ChickenArise said...

Girlie said...
after about a year on the 300 mg twice daily dosing.

What are you pairing with it?

Were you recently looking into Bactrim because you feel as if you many not get over the hump with Rifampin? Just curious as to how you feel about it overall and what you are discovering in your research of alternatives and or pairing.

I am on Mepron now...so can't do Rifampin with it. Was concerned about a backslide with Bart symptoms.

if I wasn't on Mepron...I would do the Rifampin. I think it (or Rifabutin) is the best shot - unless you're willing to risk the fluoroquinolone side effects (which I'm not)
Posted 4/8/2017 2:26 PM (GMT -5)

Girlie said...

ChickenArise said...

Girlie said...
after about a year on the 300 mg twice daily dosing.

What are you pairing with it?

Were you recently looking into Bactrim because you feel as if you many not get over the hump with Rifampin? Just curious as to how you feel about it overall and what you are discovering in your research of alternatives and or pairing.

I am on Mepron now...so can't do Rifampin with it. Was concerned about a backslide with Bart symptoms.

if I wasn't on Mepron...I would do the Rifampin. I think it (or Rifabutin) is the best shot - unless you're willing to risk the fluoroquinolone side effects (which I'm not)

By flurouqinolone I'm guessing you're referring to drugs like cipro?

I remember years ago people recommended me to avoid that drug so I also wouldn't take those either.
Posted 4/8/2017 2:33 PM (GMT -5)

Xelaetaks said...

Girlie said...

ChickenArise said...

Girlie said...
after about a year on the 300 mg twice daily dosing.

What are you pairing with it?

Were you recently looking into Bactrim because you feel as if you many not get over the hump with Rifampin? Just curious as to how you feel about it overall and what you are discovering in your research of alternatives and or pairing.

I am on Mepron now...so can't do Rifampin with it. Was concerned about a backslide with Bart symptoms.

if I wasn't on Mepron...I would do the Rifampin. I think it (or Rifabutin) is the best shot - unless you're willing to risk the fluoroquinolone side effects (which I'm not)

By flurouqinolone I'm guessing you're referring to drugs like cipro?

I remember years ago people recommended me to avoid that drug so I also wouldn't take those either.

Yes, Cipro, Levaquin.

Many people do take them with good results and no side effects. It's a personal decision.
Posted 4/8/2017 2:41 PM (GMT -5)

Xelaetaks said...

k07 said...
Make sure you keep testing liver every month.

I drink detox tea, take nac, ala, liposomal glutathione and phosphatidylcholine for liver. Many take milk thistle too.

I was fine on 300 mg 1x a day. I am upping to 600 mg after vacation.

I never understood with milk thistle if it's safe to take while drugs are active in your system. I.E. Does it interact with the bodys drug intake or something?

I do plan to take it though. Also my doctor said I could start on 300 mg once a day so I guess I'll try that out and see how it goes.

I actually have no idea about this. Never heard that before. I've taken it before but I'm always a little nervous bc I have a ragweed allergy.
Posted 4/8/2017 3:59 PM (GMT -5)
hi K07. i have ragweed allergy, too, and have taken both Rifampin and Milk Thistle together, and separately, with no problems. i did read somewhere that Milk Thistle should not be taken with Rifampin...couldnt remember why though...too complicated (for me). :D
Posted 4/8/2017 4:12 PM (GMT -5)
It has something to do with the Cytochrome P450 interaction:

www.mayoclinic.org/drugs-supplements/milk-thistle/interactions/hrb-20059806

"Milk thistle may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be increased in the blood, and may cause increased effects or potentially serious adverse reactions. "


Rifampin is a P450 drug.

"Rifampicin is the most powerful known inducer of the hepatic cytochrome P450 enzyme system,..."

/en.wikipedia.org/wiki/Rifampicin

So milk thistle would increase drug levels...but does an 'inducer' get affected? (rifampin)
Posted 4/8/2017 5:51 PM (GMT -5)

Girlie said...
It has something to do with the Cytochrome P450 interaction:

www.mayoclinic.org/drugs-supplements/milk-thistle/interactions/hrb-20059806

"Milk thistle may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be increased in the blood, and may cause increased effects or potentially serious adverse reactions. "


Rifampin is a P450 drug.

"Rifampicin is the most powerful known inducer of the hepatic cytochrome P450 enzyme system,..."

/en.wikipedia.org/wiki/Rifampicin

So milk thistle would increase drug levels...but does an 'inducer' get affected? (rifampin)

With all the writings on rifmapin and liver I think maybe I'll take it with a pusle method. Few weeks on and a week off and during the weeks off detox with milk thistle.
Posted 4/8/2017 6:17 PM (GMT -5)
I have a homeopathic liver support called Apo-Hepat by Pekana

It has kept my liver enzymes very low the entire time I've been on Rifampin.


But that is a good idea to take the milk thistle while you're on the off weeks.
Posted 4/8/2017 8:44 PM (GMT -5)

Xelaetaks said...

k07 said...
Make sure you keep testing liver every month.

I drink detox tea, take nac, ala, liposomal glutathione and phosphatidylcholine for liver. Many take milk thistle too.

I was fine on 300 mg 1x a day. I am upping to 600 mg after vacation.

I never understood with milk thistle if it's safe to take while drugs are active in your system. I.E. Does it interact with the bodys drug intake or something?

I do plan to take it though. Also my doctor said I could start on 300 mg once a day so I guess I'll try that out and see how it goes.

it is said by dr m that bart loves the liver and he pushes through treatment in apite of liver enzyme elevation ..i have heard milk thistle seals your liver protecting it but can also help harbor the pathogens inside ....i would want bart outta there so it can function better eventually...

the pulsing of rifampin is another discussion..dr h does but dr mr doesnt ...see previous threads

also it is thought that it need be paired with something like mino ,doxy or zith or biaxin so bart does not learn to resist it via efflux pump. Buhner says it essential has 2 cell walls so that what makes it so resilient. ..

i have been pairing with zith ,bee venom houttynia sida acuta and propolis (therputic grade)

Post Edited (bluelyme) : 4/8/2017 7:50:08 PM (GMT-6)

Posted 4/9/2017 9:42 AM (GMT -5)

bluelyme said...

Xelaetaks said...

k07 said...
Make sure you keep testing liver every month.

I drink detox tea, take nac, ala, liposomal glutathione and phosphatidylcholine for liver. Many take milk thistle too.

I was fine on 300 mg 1x a day. I am upping to 600 mg after vacation.

I never understood with milk thistle if it's safe to take while drugs are active in your system. I.E. Does it interact with the bodys drug intake or something?

I do plan to take it though. Also my doctor said I could start on 300 mg once a day so I guess I'll try that out and see how it goes.

it is said by dr m that bart loves the liver and he pushes through treatment in apite of liver enzyme elevation ..i have heard milk thistle seals your liver protecting it but can also help harbor the pathogens inside ....i would want bart outta there so it can function better eventually...

the pulsing of rifampin is another discussion..dr h does but dr mr doesnt ...see previous threads

also it is thought that it need be paired with something like mino ,doxy or zith or biaxin so bart does not learn to resist it via efflux pump. Buhner says it essential has 2 cell walls so that what makes it so resilient. ..

i have been pairing with zith ,bee venom houttynia sida acuta and propolis (therputic grade)

My llmd is also pairing it with doxy and tinidazole as part of my protocol. Seems like a lot of meds but I guess with long time Lyme that may not be an unusual amount of drugs.
Posted 4/9/2017 12:18 PM (GMT -5)
rifamycin class drugs (rifampin or rifabutin) are very powerful and go after lyme and bartonella quite well. i believe i made most of my progress due to this (i did rifampin for 4 months and rifabutin for 4 months also).
Posted 4/9/2017 5:13 PM (GMT -5)

Rikky1 said...
rifamycin class drugs (rifampin or rifabutin) are very powerful and go after lyme and bartonella quite well. i believe i made most of my progress due to this (i did rifampin for 4 months and rifabutin for 4 months also).

...and I've read recently that they can also bust cysts...
Posted 4/11/2017 11:36 AM (GMT -5)
From reading online it appears that pulsing rifmapn could actually be dangerous. Apparently it has caused renal failure in some people. Anyone know if that means rifmapn is only supposed to be taken once straight for however long needed?
Posted 4/11/2017 11:37 AM (GMT -5)
I remember reading that - it was maybe two or three cases ever...right?

And cessation of the Rifampin - it reversed the renal failure? Or am I not right on that.


Most LLMD's do prescribe it continuously...but there are a few LLMD's who are now using a pulsed approach, even with the Rifampin.
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