Reovirus infection triggers diet allergies and development of celiac disease

I know this is not the celiac forum but since so many of us have issues with food intolerance, i thought you would appreciate this important research paper published 2 days ago.

This kinda shows that the right virus at the wrong time can lead to life long suffering. It also shows that some autoimmune processes (in this case gluten intolerance), once started by infections (reovirus presence in early life), are going to linger even after the original infection is gone.

science.sciencemag.org/content/356/6333/44

"Viruses compound dietary pathology
Reoviruses commonly infect humans and mice asymptomatically. Bouziat et al. found that immune responses to two gut-infecting reoviruses take different paths in mice (see the Perspective by Verdu and Caminero). Both reoviruses invoked protective immune responses, but for one reovirus, when infection happened in the presence of a dietary antigen (such as gluten or ovalbumin), tolerance to the dietary antigen was lost. This was because this strain prevented the formation of tolerogenic T cells. Instead, it promoted T helper 1 immunity to the dietary antigen through interferon regulatory factor 1 signaling. Celiac disease patients also exhibited elevated levels of antibodies against reovirus.

Viral infections have been proposed to elicit pathological processes leading to the initiation of T helper 1 (TH1) immunity against dietary gluten and celiac disease (CeD). To test this hypothesis and gain insights into mechanisms underlying virus-induced loss of tolerance to dietary antigens, we developed a viral infection model that makes use of two reovirus strains that infect the intestine but differ in their immunopathological outcomes. Reovirus is an avirulent pathogen that elicits protective immunity, but we discovered that it can nonetheless disrupt intestinal immune homeostasis at inductive and effector sites of oral tolerance by suppressing peripheral regulatory T cell (pTreg) conversion and promoting TH1 immunity to dietary antigen. Initiation of TH1 immunity to dietary antigen was dependent on interferon regulatory factor 1 and dissociated from suppression of pTreg conversion, which was mediated by type-1 interferon. Last, our study in humans supports a role for infection with reovirus, a seemingly innocuous virus, in triggering the development of CeD.
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I didn't read the article but is sounded like fake news. Isn't it obvious that leaky gut + infection like in Lyme is a major factor in gluten intolerance (a condition which I doubt they acknowledge exists, like Lyme, and also an epidemic)

True celiac is a genetic disease and can be triggered by 'something'.

After our son was diagnosed with it...we read that intestinal surgery can be the trigger.
He had intestinal surgery at 5 weeks old.

This virus may be another 'trigger'.


When I first started having lyme symptoms...that was one of the tests my Dr. had me do - and I was negative on the tTG antibody test.

We still don't know which side of the family has it. No genetic testing was done on myself or my husband.