Posted 4/25/2017 6:41 PM (GMT -5)
I know Horowitz uses this strategy in regards to Rifampin. He will mix things up, either use a stronger dose, or shift dosing strategy (in the way you did, consolidating multiple doses into one). Sometimes doing this will draw out strong herxheimers from the patients, even though they are taking the same amount of drug as before. Maybe increasing the peak level of drug in the body for that small window really nails the buggers! maybe overwhelms or surprises them haha! that's what I like to imagine!