Doxy plus Knotweed = effective against round body form?

There are two pharmaceuticals that are used for cyst busting:

Flagyl and Tinidazole.

Flagyl has a black box warning because rats/mice were given flagyl and developed bladder cancer.
They extended that warning to Tinidazole because it's a similar drug.


Some LL dr.'s use GSE for cyst busting.


...and don't forget about the biofilms.

TheRhythm said...
Buhner cautions against aggressively breaking up biofilms and says that it is not necessary.

I'll look into GSE.

Have people found success in treating long term (~10yrs) Lyme with Doxy + herbs?

I'm not sure if I'd want to leave the biofilms alone...as at some point, I'd think they'd open up and release more spirochetes...and then you'd be dealing with it then.

I don't know about 10 years of treating lyme with doxy and herbs. I don't know anyone (that I can remember) who has treated 10 years.
I'm curious - Why are you asking about 10 years of treatment?

TheRhythm said...
No no, I've HAD lyme for 10 years. Gosh, I would hate to be on herbs + antibiotics for that long.

Okay - silly me.


10 years IS a long time. Although, I know several people approaching 5 years now... And I'm over 3 years now..

TheRhythm said...
Buhner cautions against aggressively breaking up biofilms and says that it is not necessary.

I'll look into GSE.

Have people found success in treating long term (~10yrs) Lyme with Doxy + herbs?

Buhner believes that long term use of herbals break biofilm, hence why he doesn't find adding a biofilm buster to his protocol necessary. He also states that it doesn't hurt to add one, so why not? I also have read that some people have success adding lumbrokinase to Buhner's protocol.

I've been on biofilm busters (Xylitol and Lactoferrin) for over a year and am not stopping even though my protocol is switching to persister cell and Bartonella focused.

There's a lot more research these days on biofilms and seems the overarching feeling is they need to be addressed. Buhner even addresses it though not indirectly since he says the herbs bust them up.

It makes sense really as bacteria are using it to survive by shielding themselves against the body's defenses. They want to survive, we don't want them to cause they make us ill so you have to root them out.

"There's a lot more research these days on biofilms and seems the overarching feeling is they need to be addressed. Buhner even addresses it though not indirectly since he says the herbs bust them up."

I think the point here is that it is important, but it's not more important than any other angle. Researchers are concerned about biofilm because they mostly rely on conventional antibiotics which are single target therapies (in theory). Herbs tend to be multipronged by nature. They tend to inhibit spreading factors, adhesins, invasins, quorum sensing, DNA synthesis, etc. Antibiotics generally target ribosomes, cell wall synthesis, OR DNA synthesis with a few exceptions. Conventional medicine is just learning to make up for what they lack by identifying one problem... and then another... and then another. That said, not all herbs bust all biofilms. So I don't quite agree with Buhners lax perspective either. If you're not getting where you want, it's a worthy thing to spend some focus on.

In regards to knotweed... there is no evidence to my knowledge of it's effectiveness on any borrelia, biofilm or not. That said... my personal experience is that it works very well. Cryptolepis and Sida acuta work very well for my disease temporarily and then it becomes tolerant and they stop working no matter how much I take. To my knowledge they both contain cryptolepine which is inhibits DNA and RNA synthesis. This is usually bacteriostatic and only works on active cell metabolism leaving it prone to drive persister cell formation like conventional antibiotics. This doesn't happen with knotweed for me. Every time I take more I herx more and then I feel even better when i stop herxing. If i had to guess I would say knotweed probably does have some action on persister cells and biofilms whereas the others tend to drive it in to these states. But that's a total guess based on my personal experience with treatment responses. I'm just making up stuff to justify my experience like everyone else. There really is very little hard data on these things in respect to Lyme.

Yeah I understand that. That's one of my gripes with it. It has done wonders for everything but my neuro symptoms. I suspect it doesn't penetrate the nervous system as well as buhners says. But maybe it's just my experience. What I'm driving at is those little bugs are clearly there and every time I stop taking knotweed it all comes roaring back. Starting with nerve symptoms and then spreading elsewhere. So dependency is an issue for me so far. Sida and crypto caused the worst neuroherxes. I thought it was game over for those little ******s but like I said they just stopped working. No more herxes, no more improvement. Nothing.