bluelyme said...
Thanks Georgia h ...so is killing gram neg in gut the only way to reduce ? How is it excrimented thru liver mech cytochrome 450 ? Kidneys ...what binds it ? Or neutralizes ..is it acidic ?
From what I've read and theorized, it's more than reducing gram negatives. I believe that there are too many gram negatives but also that the ratio of gram positives is skewed. Yes, gram negatives make most of our ammonia in our GI tract from the nitrogen in protein we eat. But with Lyme, our Lactobacillus levels drop and they are gram positive. IMO, this allows for an increase in Enterococcus and Proteobacteria. The Enterococcus is gram positive and fills the void left by the Lactobacillus. Enterococcus isn't the protective force that Lactobacillus is. This allows more gram negatives, more candida, and more pathogens. Eating the way most American's eats reduces Bifidobacterium which is gram positive. It is a protective force as well. Without these two protective forces, our immune system becomes bogged down in trying to keep our GI tract healthy and can't allocate enough antioxidants to stop all of our peripheral issues.
Ammonia is very alkaline. It is naturally produced in several place in our body but mostly the liver. What if we had a leaky gut and gram negative bacteria translocated to a shoulder or knee? They would produce ammonia there and that ammonia would need to be eliminated. This isn't inside the cells or in the blood, this would be insterstitial. Ever had a joint pop or creak? That could be the body's NO gas being utilized in eliminating ammonia. This occurring would decrease your body's available NO for fighting pathogens.
Cytochrome P450 are just various enzymes used to help eliminate various compounds.
To learn about
ammonia elimination, read about
the ornithine cycle also called the urea cycle.