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Posted 2/16/2019 2:52 AM (GMT -5)
Does anyone have experience with immune boosting peptides? I was just watching an interview with Dr. Kent H from California on his practice. He is a big proponent of immune boosting peptides such as:

BPC-157 (Aka: Body Protection Compound. Repairs body, especially leaky gut.)
LL37 (helps antibiotics work better)(Apparently kills cysts better than tindamax)
Thymosin alpha 1
Peptides to stimulate release of growth hormone
Epitalon peptide (helps with sleep)
Thymosin Beta 4 (speeds up tissue repair. Especially brain tissue)

Dr. Kent H had lyme himself while he was going through med school. Apparently he did ultra high dose abx for 3 years and didn't reach remission until he incorporated peptides.

He says that lyme causes TH2 (extra-cellular) immune cells to increase and TH1 (Intra-cellular) cells to decrease, which causes chronic lyme since the bacterias (lyme, bart, babs) hide inside cells. Apparently the peptides can help bring the TH2 and TH1 levels back to a normal balance.

Is anyone a patient of Dr. H's clinics in California? Would love to hear some first hand experience with these peptides. It seems to be a good adjunct treatment to add to abx. I'll attach a couple of interviews with Dr. H below:


https://www.youtube.com/watch?v=a_uyhd0uxzw
https://www.youtube.com/watch?v=nmw_71jtjmo&t=3603s
Posted 2/16/2019 3:05 AM (GMT -5)
BPC-157 did absolutely nothing for me

Thymosin alpha 1 is intriguing but have not tried it

Peptides to stimulate release of growth hormone - I did one of these and again it did nothing for me
Posted 2/16/2019 3:25 AM (GMT -5)
Interesting. How long did you use them? Did you test your blood before and after and note any shift in levels? TA1 does look interesting. Here is a detailed article about it's benefits:

https://www.omicsonline.org/thymosin-apha-a-peptide-immune-modulator-with-a-broad-range-of-clinical-applications-2161-1459.1000133.php?aid=19965

"Human Immunodeficiency Virus (HIV)

Acquired Immunodeficiency Syndrome (AIDS) is a disease of the human immune system caused by HIV infection. As the disease progresses, the immune system will slowly weaken, leading to a higher chance of infections that would not regularly occur in healthy patients. There is no cure or vaccine for HIV; however, antiretroviral treatments have shown to slow the course of the disease. Approximately 34 million people are living with HIV infection globally, while AIDS is considered a pandemic worldwide, having claimed more than 25 million lives (http://www.who.int/mediacentre/factsheets/fs360/en/index.html). Ta1 in combination with IFN-alpha and AZT was investigated for treatment of HIV in several studies [138,139] and several measures of response, including greater increases in CD4 cells, were seen in subjects given Ta1."
Posted 2/16/2019 10:59 AM (GMT -5)
Sheekster - Interesting you posted about HIV/Aids. Dr. J (maybe you know) was an HIV/Aids specialist prior to 'switching' to treating lyme disease.

I wonder what his thoughts would be on this.
Posted 2/16/2019 1:18 PM (GMT -5)
I visited his clinic back in may of last year. He diagnosed me with lyme and prescribed me BPC-157 (both oral and injection) and thymosin alpha but this was before I even trialed any abx for my disease. When I asked for further evidence of peptide therapy, all he gave me were links to his powerpoint slides from conferences he spoke at. Doesn't seem like his recommended treatment (ozone/peptide therapy/stem cells) is proven at the moment. Also, the clinic sells their own products... which was also fishy and $$$ to me. After about a month there, I moved on to a more solid LLMD who uses treatment based on clinical evidence from reputable sources (pubmed, etc.).

With that said, I ended up returning the peptide meds because I started abx first which was covered by my insurance and it made me feel quite a bit better. So, all this to say, I'm still curious as to how many people actually get better with peptide therapy. Yes, the idea behind it is to establish th2 balance again to get the immune system back in order so that the body would repair itself.

If you end up giving it a try, please let us know how it goes for you!
Posted 2/17/2019 3:28 AM (GMT -5)

Girlie said...
Sheekster - Interesting you posted about HIV/Aids. Dr. J (maybe you know) was an HIV/Aids specialist prior to 'switching' to treating lyme disease.

I wonder what his thoughts would be on this.

Yes I love how Dr. J comes with experience from the HIV world. This means he is familiar with immunosuppression and takes immunosuppression from lyme and co's seriously. In the 2nd interview I posted above I believe Dr. H says that he had immune suppression so bad that all the doctors he was seeing trying to get a diagnosis thought he had HIV.

I like the idea of these peptides because you can use them along with antibiotics, they assist in repairing tissue damage from lyme, and they boost the immune system, which is needed because of immune dis-regulation from lyme and you also need a functioning immune system to take over the job where the abx left off. Some antibiotics are bacteriostatic meaning they only prevent further bacteria growth and require a functioning immune system to kill of the current bacteria.
Posted 2/17/2019 3:38 AM (GMT -5)

xpeetzax said...
I visited his clinic back in may of last year. He diagnosed me with lyme and prescribed me BPC-157 (both oral and injection) and thymosin alpha but this was before I even trialed any abx for my disease. When I asked for further evidence of peptide therapy, all he gave me were links to his powerpoint slides from conferences he spoke at. Doesn't seem like his recommended treatment (ozone/peptide therapy/stem cells) is proven at the moment. Also, the clinic sells their own products... which was also fishy and $$$ to me. After about a month there, I moved on to a more solid LLMD who uses treatment based on clinical evidence from reputable sources (pubmed, etc.).

With that said, I ended up returning the peptide meds because I started abx first which was covered by my insurance and it made me feel quite a bit better. So, all this to say, I'm still curious as to how many people actually get better with peptide therapy. Yes, the idea behind it is to establish th2 balance again to get the immune system back in order so that the body would repair itself.

If you end up giving it a try, please let us know how it goes for you!

You don't happen to have those powerpoints do you? I would love to see those. That is interesting. How long did you give the peptides a try for? Did you notice any difference? Did you see Dr. H himself? I got his prices and he charges $500 every 15 minutes. No thanks. I'll go to one of the other doctors at his clinic for $595.

I am glad you are feeling better on abx alone. I have been through 3 LLN/MDs and I am now at my final destination, which is the JSC in WA DC. Abx alone didn't seem to do the trick for me, or it is working very slowly. However I have other issues than just lyme, so that is why I am interested in peptide therapy. Something to cover the other bases while at the same time taking abx...

In Dr. H's interviews I posted he mentioned that they use abx along with peptides at his clinic. I am surprised he didn't offer them to you. He claims that one of the doctors beneath him doesn't use abx for lyme patients and is still getting good results. If I go I will definitely keep on my pulsed abx regimen. You can buy these peptides at places other than through his clinic, but I have a feeling they will encourage you to buy direct from them due to quality concerns... who knows where some of this stuff on the internet comes from...
Posted 2/18/2019 1:30 PM (GMT -5)
I do still have them, if you would like to see them, shoot me an email.
Posted 2/18/2019 2:19 PM (GMT -5)
Girlie-

Since Dr J knows AIDS; has he paid more attention to and test immune cell levels : WBC > CD57 >, then B, T, NK , and immunoglobulins?
Posted 2/18/2019 2:21 PM (GMT -5)
I keep meaning to learn more about: th1 / th2 balance.

Are there standard lab tests for this to keep cost down, like Quest and LabCorp?
Posted 2/18/2019 2:32 PM (GMT -5)
We occasionally read about "this or that" being immune boosting. OK. (?) But.....the "immune system" is a buzz word, and seldom do "they" go into details. I like details, and proof.

Just what part of the immune system do peptides "boost"? (I did not click on the you tube links).

I've been trying to boost B,T and immunoglobulins, and have a post-lyme baseline of my levels several times, so, no guessing.

As far as I understand , th1 and th2 is about balance, not levels?
Posted 2/18/2019 8:09 PM (GMT -5)

astroman said...
Girlie-

Since Dr J knows AIDS; has he paid more attention to and test immune cell levels : WBC > CD57 >, then B, T, NK , and immunoglobulins?

He tests WBC count
not the rest - not with me anyway.
Posted 2/18/2019 8:54 PM (GMT -5)

xpeetzax said...
I do still have them, if you would like to see them, shoot me an email.

Email sent.
Posted 2/18/2019 8:55 PM (GMT -5)

RainyCloud said...
Just to add to my own comment, you can ask vendors of peptides for a HPLC (lab purity test) to ensure purity.

Never buy peptides online without HPLC.

Email sent.
Posted 2/20/2019 11:13 PM (GMT -5)

astroman said...
Girlie-

Since Dr J knows AIDS; has he paid more attention to and test immune cell levels : WBC > CD57 >, then B, T, NK , and immunoglobulins?

After my first appointment at the JSC the PA had me test for a lot of immune markers. I'll list off the majority of them:

Immunoglobulin G, A, M serum
Immunoglobulin E
Thyroid Peroxidase
Thyroglobulin Antibody
Vitamin D 25 hydroxy
Iodine
WBC
CD19 + lymphs
CD 3
CD 4 Helper
% CD 3 Pos. Lymph
% CD 4 Pos. Lymph
Abs. CD 8 Suppressor
% CD 8 Pos. Lymph
CD4/CD8 Ratio
CoQ10
Vitamin B1
Testosterone
TSH+T4F+T3Free+T3Reve
Carnitine
Zinc
Copper
B vitamin levels
Posted 2/21/2019 12:08 AM (GMT -5)

astroman said...
We occasionally read about "this or that" being immune boosting. OK. (?) But.....the "immune system" is a buzz word, and seldom do "they" go into details. I like details, and proof.

Just what part of the immune system do peptides "boost"? (I did not click on the you tube links).

I've been trying to boost B,T and immunoglobulins, and have a post-lyme baseline of my levels several times, so, no guessing.

As far as I understand , th1 and th2 is about balance, not levels?

Of course... there are specifics out there, but I used immune boosting peptides as a generalization. For example BPC 157 is more of a healing and protection peptide. Thymosin Alpha 1 works to increase TH1, which is an intracellular immune response... here is a summary from Kent H about the benefits of the Thymic Peptides (the numbers at the end of each statement are references):

Improved tissue repair and healing35,36,37,41
 Improved host defense to infection26,27,28,29,30
 Reverse immunosuppression of chronic infection (Lyme)24,26,27,28,29,33,34,37,
 Increases antioxidant and glutathione production26,27,28,31,28,29,63,66
 Boost NK function26,35
 TH2-TH1 immune modulation (infections, cancer, herxheimer,
autoimmune)26,27,28,30,31,33
 Bind neuro/endotoxins111
 Cardiac regeneration and protection post-MI, CHF, etc.39,65,98,99,100
 Neurologic regeneration and protection post-stroke, TBI, Lyme,
Alzheimer’s, neuropathy, Parkinson‘s, etc.63,67,42
 Stimulate stem cell activity and proliferation32,34,36,38,40,41,42
 Increases longevity89,90,91
 Almost non-existent side effects at 100-fold dose+ excess103,104
 Excellent safety profile with large therapeutic window (over 1000 fold)

Here is a good short article on Th1 / Th2 and how to raise TH1 levels.

https://selfhacked.com/blog/supplements-people-th2-dominant/

LL37 is an antimicrobial peptide beyond that I haven't read much, but I just found this study and plan on reading up on it.

https://www.ncbi.nlm.nih.gov/pmc/articles/pmc3836506/
Posted 2/21/2019 12:09 AM (GMT -5)

RainyCloud said...
Just a heads up, you can buy a lot of these peptides online without prescription.

Let me know if anyone needs help finding them.

I was shocked at some of the prices in this thread.

Also, don't take BPC-157 if you're on Adderall.

Rainy if you could provide me with a source that would be most appreciated. Thank you.
Posted 2/21/2019 2:37 AM (GMT -5)
I never had all those done....I'll bold the ones I did.


Immunoglobulin G, A, M serum
Immunoglobulin E
Thyroid Peroxidase
Thyroglobulin Antibody
Vitamin D 25 hydroxy
Iodine
WBC
CD19 + lymphs
CD 3
CD 4 Helper
% CD 3 Pos. Lymph
% CD 4 Pos. Lymph
Abs. CD 8 Suppressor
% CD 8 Pos. Lymph
CD4/CD8 Ratio
CoQ10
Vitamin B1
Testosterone
TSH+T4F+T3Free+T3Reve
Carnitine
Zinc
Copper
B vitamin levels

Sheeks - Were you discussing with the PA that you wanted to test for immune function in particular?


I'm pretty sure I had others' done that you didn't list....is that your complete list of tests done?
Posted 2/21/2019 2:52 AM (GMT -5)
No. KF did it on her own accord. I didn't list everything that I had done. What did you have done?
Posted 2/21/2019 3:13 AM (GMT -5)

Sheekster said...
No. KF did it on her own accord. I didn't list everything that I had done. What did you have done?

Hmmm - I wonder why those weren’t on my list.

I will go through my papers and list the others I had done - a few of them I couldn’t even get done here in Canada - so I had to wait several months to test when I went back to the J clinic and went upstairs to the Quest lab ( one was Ammonia)

My papers are upstairs in the bedroom and hubby is sleeping so I can’t go in there and get them -
Tomorrow I will tho.
Posted 3/6/2020 3:42 PM (GMT -5)
Hi there,
please, I need some help with search of good source of peptides with HPLC.

Best, when source is in Europe.

Sure, I found some, but with uncertain quality.
As only good source I know https://tailormadecompounding.com/ but no see option to buy.

Thanks a lot with help friends!
Martin
Posted 3/6/2020 6:57 PM (GMT -5)
I spoke w the Tribeca Wellness Collective yesterday so this is an interesting thread. They do peptides and stem cells. I was interested in the Thymosin Alpha 1 for my AI issue, but in the back of my mind I know I’m a fool just throwing his money away. If this stuff really worked wouldn’t we know? It ticks me off that there are so many people out there selling their alternative medicine cure alls, and you get excited, and they promise you’ll get better, and it never works. But of course im desperate so I will continue to do it. All they’re selling is hope I guess.

Anyway, is there anyone who has tried Thymosin Alpha 1 for an AI issue, and how did it work?

As for Th1/Th2, Th1 basically means cell mediated/T cell. Which means it kills pathogens inside cells. Since it’s cell mediated and cell mediated relies on cytokines (which alert the innate immune system like macrophages to help out), it tends to be more inflammatory. Th2 is B cell/humoral and intercellular. Usually not inflammatory, is driven by antibodies.

But this is an old model. We know there’s both cell mediated and humoral responses in most AI issues. B cells are antigen presenting cells to T cells and release cytokines through the compliments, and T cells activate B cells often. Not sure this Th1/Th2 testing means anything, although could be wrong. I need to learn more about what Astro posted about a while back, toll like receptors and the inhibition of the innate immune system. Seemed interesting. Been too sick tho.
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