Should we even treat MTHFR? How to know

I’ll begin by updating my daughter Blakeley’s condition. Last time I posted about her, she was having horrible days in bed with very little progress.
I took her off methyl protect and supplements which were recommended to treat MTHFR. I also started Zyrtec and curcumin daily.

She has had 20 days in October where she’s up out of bed and taking care of herself in the house. I mean, still symptoms and not normal, but so much better than feeling like her body is dying.

Currently, however, she is back in bed feeling terrible but we expected that to come again.

I’m not sure if stopping the MTHFR supplements helped or what. She prob does need to be taking them but how do I know? How do I start slowly when the capsule contains 1000 mcg?

Any guidance regarding how to/if to treat MTHFR and what to expect when doing so would be greatly appreciated.

My guess would be that the Zyrtec and curcumin are what turned things around for her, especially if she has any issues with mast cell activation, as so many of us do. Curcumin is such a rockstar anti-inflammatory. I doubt the methylated B12 and folate were hurting her because B vitamins are water soluble, so our bodies are very good at excreting what we don't need (hence the bright yellow pee when we supplement). I am SO glad to hear that she has been doing better this month. What a relief that must be for both of you!

This was the first month we used curcumin. I bought the NOW brand before even researching it. I didn’t even know about poor absorption but now I see that. I don’t know if that’s what is helping her or if she’s absorbing it but something’s causing improvement....finally!!