I came across this article that I thought gave very good detailed information regarding CIRS labs. Most think only of mold in relation to CIRS, but Lyme also causes CIRS.
As you may know, ISEAI began with a group of Shoemaker certified doctors who broke away from the rigid adherence to the Shoemaker protocol. This article explains things that I hadn’t heard before - i.e. why C4a and C3a are only valid (according to Shoemaker if sent to National Jewish vs Labcorp.
Also discusses other conditions which may be involved with some of these lab markers.
Those with an interest in autoimmunity may find this informative.
https://metabolichealing.com/cirs-testing-chronic-inflammatory-response-syndrome-may-critical