Posted 11/18/2022 6:19 PM (GMT -5)
I don't know of MTHFR playing a significant role in the metabolism of most drugs including anesthetics.
However, impaired detox, cytochrome p450, or kidney function can certainly be a risk. Also anesthetics tend to lower blood pressure, if you have autonomic instability or HPA dysfunction this can be a risk due to unstable blood pressure.