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Treating Complex Chronic Diseases: Novel Therapeutic Options For Lyme Patients

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Posted 1/28/2023 11:05 PM (GMT -5)
Link: https://www.bayarealyme.org/blog/treating-complex-chronic-diseases-novel-therapeutic-options-for-lyme-patients/

Contents:

  • What is “Precision Medicine”?
  • Human Energy and Mitochondrial Function
  • Telomeres and Cellular Aging
  • Regenerative Therapies and Exosomes
  • The Body’s Structure and Craniocervical Instability
  • Jaw Misalignment, CCI and Spinal Issues
  • Viruses and Body Decompensation
  • mTOR Agents and Autophagy
  • Toxic Load, Nutrient Status and Environmental Stressors

This part in particular caught my attention:

"Trying to increase one’s autophagy through the use of things like Rapamycin is starting to get attention nationwide. At the 2022 ILADS conference in Orlando, I met with many people who are starting to use this cancer drug in low doses to try to increase the body’s ability to rid itself of debris. Other things include Honokiol, which is a magnolia leaf, and doxycycline, and many other agents increase autophagy including methylene blue. This is one of those areas that we’re exploring as a group, and one of the ways that we approach these complicated patients. Vitamin D is another example of an mTOR agent."
Posted 1/29/2023 11:25 AM (GMT -5)
i also have the feeling methylene blue does things other than antimicrobial actions

i read that in low doses it can help mitochondria by supplying electrons into the cycle -
and its known to have mild anti-depressant qualities

it also feels like it does something different - which could be the autophagy type effects - as for me it was v hard to work up to the target doses - which are still v low compared to malaria doses - but still took many months - much harder than most antibiotics - which last time i tried - i could take at full doses - and just feel a bit worse for 4-6 weeks

its more like herbs in this respect - the intensity of herx

i haven't read the article - are they suggesting these treatments are stand alone or supportive therapies
Posted 1/30/2023 1:22 AM (GMT -5)
Hey Garzie,

I've also read about methylene blue having many other benefits besides its antimicrobial effects. The mild anti-depressant qualities might be because it's a MAOI inhibitor.

To answer your question, it depends on the part of the article but as for the autophagy my understanding is that it's more as an adjunct for people who are stuck in their treatment:

"People who have high levels of autophagy can heal, because there’s cellular turnover and new healthy cells taking the place of old or unruly cells. There are many agents that we’re starting to look at for people who have been sluggish, who have been sick for many years, and have been through many different treatments and have been stagnant."

I personally think the Honokiol suggestion is worth looking into, as its easy to get as supplement and most likely relatively safe. Rapamycin might be too much for me without medical supervision.
Posted 1/30/2023 7:34 AM (GMT -5)
yeah - that makes sense

there are an almost limitless number of possible adjunct therapies
each have their proponents - who are often passionate about this one or that one - many of them may will have some benefit - but not all - and they are likely on a spectrum

the way i see it is: any time you can do something that helps the body heal, or metabolize toxins, or reduce stress, or promote circulation, or reduce inflammation or upregulate favourable epigenetic mechanisms etc etc - you have the potential to aid the recovery process.

but since none on their own are sufficient to combat the disease and there are only so many we can incorporate into our regime - the key thing becomes:
"which of these are worth the time and expense of building into your routine?"

that key question is the tricky one
there are not enough years in a lifetime to try all of them for long enough to have a clear idea if or how much it helps by pure trial and error -

so i feel we need some systematic method of deciding which to even try - and that would be best built on some overriding concept of our illness that could inform more strategic decisions about which would fit into, and be synergistic with, the other elements and phases of treatment as part of a long term treatment strategy.

i see a lot of people targeting what are essentially adjunct treatments as the answer to their illness.

on the HBOT thread i mentioned there was one guy who had a very good outcome - and presented it as a cure all for Lyme - and co infections - and what ever else was making people ill.

then a lot of hopeful people jumped on wanting more details and going out and buying $10k chambers - and there was a great deal of push back towards other very well intentioned souls who came on to the thread to offer their own more moderate experience with HBOT over several years, and scientific references that pointed towards it being more of a suppressive treatment than a cure.
it illustrated that people really want to believe in silver bullets - even if the evidence was not there.

i have said it before - but especially if we have been ill for a number of years - i think the real solution is a multi pronged treatment approach used very strategically over time.
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