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Gilbert's syndrome/ high bilirubin from UGT1A1 gene/ Juandice/ + linked to pale/clay looking poo

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Posted 8/16/2023 2:10 PM (GMT -5)
I didnt know this part about color.....

https://gizmodo.com/yellow-poop-is-hereditary-who-knew-1721472863

"Yellow Poop is Hereditary. Who Knew?"

(Other places say more clay color vs yellow. Ive never pooped out a little yellow school bus.....clay color, yes and its weird.)

"........Sometimes their blood bilirubin levels are slightly elevated, but it rarely becomes a problem.
There is one major symptom, though. Bilirubin is a yellow-brown color. When it’s excreted, it’s excreted through feces. In fact, it’s the main coloring agent in feces. Enough bilirubin turns poop brown. When something stops bilirubin from getting excreted, poop is a yellow to light tan color. Since someone with Gilbert syndrome is generally not processing the same amount of bilirubin a normal person is, and since Gilbert syndrome is hereditary, pooping yellow or tan is an inherited trait...."

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I have double copies of the UGT1A1gene. (known since about eight years ago)

My Bilirubin has been occasionally elevated on the standard blood test panel for three decades (my whole adult life).

I just had a "standard blood panel" test, so I will look to see if its elevated again. If it is, that explains part what I'm seeing in the toilet(!)

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Then if your also on or near the keto diet (with more fats), this can also cause lighter colored poo... (which for normal people may correct after a few weeks appaently, or at least might correct with additional bile supplement, and maybe a liver/gall bladder flush (per Garzie on another post of mine,..and google).
Posted 8/16/2023 3:14 PM (GMT -5)
I had yellow stools for ages - like a school bus or a lemon - and it took me ages to figure out why. The school bus was from supplementing quercetin and curcumin. The lemon was on days I supplemented quercetin and curcumin plus calcium. I was so freaked out and convinced my pancreas was failing or some other major problem.

This isn't entirely relevant to this post, but I wanted to mention it in case anyone else is going down the yellow poop internet rabbit hole....
Posted 8/16/2023 4:08 PM (GMT -5)
I probably have Gilbert's syndrome, but the main reason my bilirubin was elevated was bartonella attacking the red blood cells.
Posted 8/16/2023 4:48 PM (GMT -5)

Quin said...
I probably have Gilbert's syndrome, but the main reason my bilirubin was elevated was bartonella attacking the red blood cells.

Hmm. Ok,

How would bart "draw" more Bilirubin out of the liver and into your blood cells?

Was Bart was in your liver and backing up flow?,.... and then that improved with other bart symptoms improving? Did you track alt/ast?
Posted 8/16/2023 5:10 PM (GMT -5)
Bartonella (and also babesia) invades the red blood cells to take iron and heme. When hemoglobin is broken down, it forms bilirubin.

I do occasionally get light colored poop, but when my bilirubin was high, my poo would be dark brown and my urine would be dark yellow. My liver was fine, and my alt/ast was fine.
Posted 8/16/2023 5:50 PM (GMT -5)
this link on "Gilbert's syndrome/ high bilirubin", is a little easier understood:

https://my.clevelandclinic.org/health/diseases/17661-gilberts-syndrome
Posted 8/17/2023 1:06 AM (GMT -5)
The whites of my eyes were yellow for many years.
Started in my teens. I was told I had Gilbert’s Syndrome.

I do wonder if it was from Bartonella - and I was not diagnosed until many years later…

My poop wasn’t yellow tho but I did have chronic diarrhea
Posted 8/17/2023 4:55 AM (GMT -5)
bart and babs cause higher than normal turnover of red blood cells

ie more are broken down in the liver than normal - and this will cause higher bilirubin in the bile and ultimately in the blood stools and urine too

so this would explain jaundice like symptoms in persons with bart/babs - but who do not necessarily have Gilberts - eg as Girlie describes - we know bart inflames the liver and likely upsets its normal function as well

in persons with gilberts syndrome with bart or babs - you could then expect exacerbated bilirubin levels and perhaps other symptoms - as they are less able to break down and excrete bilirubin - so if more is being made from red cell turnover - levels will typically be higher

as far as i can see - with bart and or babs the body goes through phases of killing off increased levels of red blood cells as it detects infection and then quiescent phases when it settles down again -
it may simply be detecting flares of infected red blood cells - or there is some evidence of a kind of cyclic auto-immune mild haemolytic anaemia - triggered by infection.
( i was diagnosed with this some years ago - at oxford as part of a study they tested me for the 40 known markers of hereditary haemolytic anaemia and found none of them - so they just gave up looking for why it was happening - the haematologists didn't know and the ID people could not detect anything - but we now know it as bart all along)

my blood tests in the past would show up vague anomalies like this - mildly elevated markers for things like bilirubin every so often - then returning to normal range a few weeks later - mildly elevated liver enzymes - again only now and then - other markers just a fraction off - or on upper/lower limit

conventional doctors never see them as significant - but those markers are set around the 95% percentile - and we all know how sick we can feel while having all markers within normal range - so having several of these pop up here and there on subsequent tests is definitely a sign something is going on
Posted 8/17/2023 3:06 PM (GMT -5)
Good discussion here about this.

I also had an elevated bilirubin pre symptoms. Which got worse in the thick of things.

Also may be worth noting the glucoronidation pathway handles bilirubin - as well as a slew of other toxins that aren’t broken down via glutathione or whatever other pathway.

While supplementing calcium d-glucarate and treating RBC infections I had a period of normalization of bilirubin levels. This however didn’t coincide with any change in clinical presentation symptom wise.
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