interesting article - thanks for posting
a little more detail for anyone reading who may be interested
the article relates to dendritic cell and then downstream T cell responses to borrelia being abnormal in Lyme patients - this is a new finding.
article said...
When everything is working right, activated dendritic cells provide three signals to T cells (signals 1, 2 & 3) that synergize to generate a strong T cell activation.
In a 2023 Johns Hopkins study, using proteomics and genomics-based approaches, researchers found that DCs exposed to Borrelia burgdorferi were fully capable of generating signal 1 but signals 2 & 3 were abnormal. In fact, the features discovered overlapped with what is found in a tumor microenvironment, a site where immune responses are known to be suppressed and dysregulated.
good to see another johns hopkins professor working on lyme - as i think Zhang will retire soon