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Mechanisms of LDN that restore Immune Function (partially)

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Posted 1/15/2024 3:25 PM (GMT -5)
So I have found this interesting study:

https://www.mdpi.com/2076-3271/6/4/82

study said...

Outcomes have shown a significant decrease in inflammatory cytokine levels, notably IL-6, TNF-α, transforming growth factor (TGF)-β, IL-17, IL-1, IL-2, and interferon-α.

Most interestingly is the reduction of TGF-beta.
TGF-beta is increased through 1,25-OH2-VitaminD3 and chronic processes and very often upregulated in chronic lyme, chronic mold and other me/cfs(umbrella term) issues

TGF-beta is known to decrease other immune cytokines and by that decreasing natural immune response and producing a low grade chronic inflammation.

Look what AI said about TGF-beta:

edit: removed a Bad AI Text

TL DR:
LDN should be able to (partially) restore immune function in chronic issues by decreasing TGF-beta.

Hope this helps someone.

Post Edited (BlazerGermany) : 1/16/2024 12:34:41 AM (GMT-8)

Posted 1/15/2024 6:46 PM (GMT -5)
unfortunately AI generated text is riddled with mistakes

eg - it has this backwards -

AI said...
It can promote inflammation by inhibiting the production of proinflammatory cytokines, such as IL-1, IL-6, and TNF-alpha.



its just guessing what word likely comes next - i would fact check anything it comes up with thoroughly

i do think LDN can help lower inflammation - at least to some extent - however if infections are continuing to needle the immune system it can only do so much in my view and in my own experience.
still, i think it helped a bit and is worth trying
Posted 1/15/2024 8:01 PM (GMT -5)
I wonder how many tried LDN but had to stop due to side effects. Or if people found it helped.

Every time I tried it, after three days I would get migraines and unstable mood. . Same with hydroxychloroquine. Really need to try on or other but haven’t gotten through those barriers.
Posted 1/16/2024 3:32 AM (GMT -5)
I have checked it again and the ai Text is in fact very stupid. Sorry about that

None the less it should work in theory at least, since the Main Body of Literature comes from the study.
Posted 1/16/2024 7:43 AM (GMT -5)

running wild said...
I wonder how many tried LDN but had to stop due to side effects. Or if people found it helped.

Every time I tried it, after three days I would get migraines and unstable mood. . Same with hydroxychloroquine. Really need to try on or other but haven’t gotten through those barriers.

its best viewed as a highly unusual radically different medication than just an anti-inflammatory

i had useful results from it - but its well known that those who are suffering from auto-immune disease - or are generally reactive need to go super low and slow with a very individualised treatment approach

i am only moderately sensitive and had to start at fractions of a milligram a day and increment by only 1/100ths of a milligram every few days to manage the adverse reactions during the ramp up phase.

very few doctors - even alternative or functional doctors get this and tend to put patients on too high a dose from the start - or just put them on a fixed dose - which is not how LDN is supposed to be used if you read on the LDN research trusts website

so while you have "tried it" - i wonder if you have tried it as its meant to be used - or just "as prescribed"

if i was a v sensitive patient like you RW - i would start on 0.01mg per day and edge up from there
all of the benefits come in the ramp up phase so its not about getting to target dose that matters
Posted 1/20/2024 3:21 PM (GMT -5)
Just for the record, yes, I’m in total agreement with the fact that information from AI is not always 100% correct. Because so far it isn’t.

**AI gathers an average of information that is available on the Internet, which makes sense since It cannot think or reason on its own yet. **

So,…If the general information on the Internet is wrong to begin with from other individuals, AI is going to average that wrong information, and repeat that same wrong information.

I have heard this and witnessed it myself and from other individuals seeking very specific information. Some perfect examples: modern car repair information (having to do with specific, yearly system sensors and diagnostics ) and or technology type information such as the differences between computer system variations / which updates, and specific phone brands and models. There is a lot of miss information out there, and AI will not know the difference as long as individuals keep posting misinformation.

I kind of like that. As it means, we cannot depend on AI for the real truth. Whatever it is, you still have to do a lot of digging.

Post Edited (astroman) : 1/20/2024 12:24:01 PM (GMT-8)

Posted 1/20/2024 3:31 PM (GMT -5)
its actually much worse than that

it has no concept of what we are asking it - only a probabilistic model of what words should come next in what order

this why it got things completely 180 degrees reversed in the initial example - not because somebody wrote it reversed somewhere on the interest - but because it can look at words the right way around and still regurgitate them back to us the wrong way around.

it has no knowledge of what is "the right way around"
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