Has anyone gotten a TH1-TH2-TH17 Test?

Hey, so i recently got my Th1 th2 stuff tested suspecting my TH1 may be supressed as commonly found in chronic infections and other me/cfs Like conditions.

I was very surprised to See my th1 immune Response is very very strongly activated.

This seems to be indicative of an overreactive immune Response rather than an underreactive.

Please Help me Interpret this, ITS really confusing for me.

I also Had to Stop LDN recently because i got really severe..

Link to the Lab Test:
https://ibb.co/ww6gjxm

The whole th1-th2 balance thing is confusing as well. I seem to see two styles of thinking.

1. The people who say chronic infections make you th2 (antibody) dominate, reducing th1. Further theorizing it’s like shooting down incoming missiles but never destroying the factory they come from.

2. The CIRS people. Shoemaker picked those markers as “innate immune system markers”. Theorizing when the body can’t modulate a more suited response for a specific threat - switching the immune system from innate response to adaptive - the innate immune response never turns off in these cases - and even furthers its response out of desperation. These people by this description are actually th1 dominate..

Hence the solution is not a lack of strength of the immune system. But a dysfunctional approach of sorts that the real understanding is probably more nuanced then we can sort out currently.

I don’t know if th1 is “self attacking”. I imagine an ANA would rule that out. I think of self attacking as like an improper anti body that shouldn’t be there.

Inflammation is just inflammation that may be causing collateral “damage” symptom wise. Dr. Neil Nathan says it’s the rule not exception that when inflammation goes away so does symptoms. There can me “damage” but it’s described as an outlier by him.

Boswellia will reduce mmp-9. I’m sure there’s some cross coverage amongst the group.

I’ve taken curcumin regularly for a few years. Good for inflammation.

It’s also my experience that the immune system isn’t stupid and isn’t just “stuck” without cause. I believe this is also why people can react poorly to peptides. It also needs to be respected in its current state.

that is very interesting garzie. that could possibly be the case. i should have gotten another test while not on it to compare it.

i think a good idea would be (if i can handle it financially) to keep ldn out of my system for now and retest in 1-2 weeks to see if anything changed.

maybe retesting and starting at a way lower point of ldn so that my body can actually handle it might be the way to go for the future.

anyway - thanks for helping me with this @all !

I haven't had this test myself but I recall Dr Myhill talking about how MCAS is an inflammatory response driven by allergens, multiple infections and the fermenting gut. She said to do all the interventions to damp down inflammation to switch from th1 to th2 state. She said these can all be used generally to reduce inflammation not just for MCAS

She recommends the following:
do the paleo ketogenic diet
take vit c to bowel tolerance / high dose vitamin c
Vit d
High dose vit c
Magnesium (this stabilises cells)
Omega oils
Cbd
Low dose naltrexone
B12
Detoxing
Certain herbs

Dr Klinghardt also talks about TH1 / TH2 dominance - he says he sees one more commonly with lyme and chronic infection and the other with cancer but I can't remember which way around he said. So you are likely to either have chronic infection or cancer but not both

Dr Mark Su says that TH2 dominance is usually seen with parasitic infections

Curious what is the reason you did this test?

Also re cortisol - our body makes cortisol naturally so if you have low cortisol on a salvia or blood test and are taking a physiological dose of 20-30mg up to twice per day this is not immuno suppressive because it's what our bodies make naturally. When you go above these doses it is when it can become immuno suppressive. It's advised to avoid these high doses when someone has chronic infections because they can suppress the immune system and cause the infections to flare up. Don't quote me on these exact dosages, definitely do some research before starting it's just what I have learnt from a couple of different doctors

Post Edited (emma blonde voyage) : 2/11/2024 4:02:40 AM (GMT-8)

Hi blazer thanks for explaining, so now I'm curious if your th1 had been surpressed, what would your plan of action have been? and would it have changed your treatment plan going forward? sorry I know it's not relevant to you now but I am learning so interested

edit: listening to this Q&A with Dr Marty ross who recommends peptide BPC517 to help balance out the immune system. I know you mentioned you took peptides previously so maybe something to consider for future?

Post Edited (emma blonde voyage) : 2/12/2024 6:31:52 AM (GMT-8)