new antibiotic -

its not directed specifically at lyme

but its particularly targeted at drug resistant or drug tolerant bacteria and biofilm forming infections - so it should be highly applicable.

its not often that an entirely new class of antibiotic is found so this is quite a big step

that said - there is likely still a long way to go before it could be used in humans - but unlike things like Hygromycin-A - which was not expected to be effective against persister cells or biofilms - or the Haystead light activated targeted antibiotics - which would be - but at present need light to penetrate through the entire host tissues.

this is a drug specifically for chronic infections that have already had the chance to build up biofilms and populations persister cells and doesn't need x-rays or light beams to activate it

looks like ys at animal trails stage - so its like a good way from being used in the clinic - but i thought it worth a mention anyway
[url]https://phys.org/news/2024-02-molecules-class-antibiotics-drug-resistant.html{/url]

yep - its a long way from the clinic -

but it represent a completely new approach - specifically targeting bacteria that are in biofilm colonies as found in all chronic infections - whereas most / all existing antibiotics were developed targeting planktonic and logarithmic growth phases - and some just happened to also have some activity against bacteria in biofilms - but typically these were not really effective against these biofilms forms unless concentrations were 1000x those needed for planktonic forms. which is why we end up on such long term antibiotics and often then they are often only partially effective

so - while its still at discovery stage - its a sign that there are at least avenues of research that could help in the long run