StevenDallas- seems the 10+ years idea is reasonable, John T has posted info along that line many times, epithelial cells go through changes towards abnormal cells structures, first can be identified in pathology via PIN and later could be morphing to HG-PIN (considered pre-cancerous prostate cells), later maybe changing into measurable Gleason scores, commonly lower grade scores first in most cases, unless one is dealing with a discovered variant type of PCa (some of those are aggressive or do different things as to psa levels expressed) or discovered years later and PCa has set up shop a longer while and if DNA ploidy changes to the worse level becoming totally random DNA chain breaks, thus uncontrollable cell changes (3 categories exist on Ploidy). (my thoughts) On the forum over at
www.yananow.org Terry H. has weblinks and information showing the evidence on PIN and becoming cancerous has plenty of controversies and is not established as 'known fact of PCa', so will assume his info is really good, I have alot of acolades for Terry's input and researches, so if you are real curious visit his threat reply on that (Pratoman possed the question there, good question and good answer by Terry).
My brother had psa of 1.0, but DRE seemed positive, pathology showed 1 core positive Gleason 6...he is done monitoring for over 9 yrs. now and that seems sane in his case (W.W.=A.S.) He had what is considered indolent PCa, less than 5% volume in that core.
Food for thought anyway, lol when is anything in PCa totally black and white and simplistic??? Exceptions are all over the map. Still good to look over anything and everything. Psa is not cancer specific, although can be very useful as a tool, other markers and tests define cancer better.
Post Edited (zufus) : 12/12/2012 5:18:50 AM (GMT-7)