Xgeva and Zytiga together.

Been quite a while since I have posted. I will be starting Zytiga in March. Eligard has stopped working after two years. My doctor said that I can't take Zytiga and exgiva together. Anyone have any experience with this. Gotta protect those bones.

Thanks,
George

Hello! My husband is about to start on Zytiga, too (the oncologist just called to tell him he was not accepted in the clinical trial for GTX-758 so we are moving on to Zytiga). Dr. Flaig did not mention anything about the Xgeva, which Marshall also takes. I guess we'll learn more about that later.

But your posts bring up another question: Marshall has been having SEVERE bone pain for the past month and our oncologist has done several sets of x-rays and scans and he does not believe the pain is totally cancer related. I had read that sometimes Xgeva causes bone pain and that if you switch to another bone strengthener like Zometa the bone pain stops.

I asked Dr. Flaig about that and he said that is possible, but that he feels Zometa is too toxic.

Do any of you have any opinions or experience with this?
Marilyn

Here's my 2 cents worth: Husband on Xgeva, Xtandi and Trelstar. Bone pain is side effect of Xgeva and Xtandi. Zometa is an infusion where Xgeva is an im injection (meds are frozen and need to be thawed out for about 20 minutes before injecting). Sometimes pain more severe than usual but able to take lortab and it(pain) subsides. Suspect that if Xtandi fails then Zytiga will be the next process for us......