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Posted 3/5/2014 1:53 PM (GMT -5)

In January I completed PROVENGE therapy and am happy to report my PSA went from 13.6 in December to 5.04 end of February.

I am thinking of asking the oncologist to go ahead and start me on Xtandi if my insureance allows it. I have heard of others doing this with good results. My doctor has mentioned taking DES if my PSA rises but I am not so sure of doing this after reading up on it. What is your take on this?

Posted 3/5/2014 2:28 PM (GMT -5)
It has been found that 1 mg of DES is considered very safe (5 mg unsafe) (Journal of Urology article Nov. 2003) It can work on hrpca cells, when casodex or Lupron fails, however like anything no guarantees. I did 2 yrs. of ADT3 2002-2004 and it was starting to fail psa control, switched to DES 1 mg, got excellent results for about 8 years and then it quit working and now onto other drugs, currently Zytiga. It is not the blood clot killer story, you get screened for risk and get an INR protime blood coagulation test and use Coumadin or aspirin along with it. I never had a problem with it, no nasty side effects, it even builds bone density and assists your memory of which LHRH drugs ruin both of those over time. Of course there is no money in selling DES, the original patent died around 1982 ? when Lupron introduced.
Posted 3/5/2014 6:18 PM (GMT -5)
That's was a nice drop from the Provenge. Congratulations.
Posted 3/5/2014 7:18 PM (GMT -5)
I agree with Purg...I don't think I remember too many Provenge guys actually having psa go down on Provenge only...usually I hear you can't judge how effective Provenge is working based on psa...but that is usually mentioned when psa was going up or staying relatively the same ..nice to see it come down...

I think if it was me I'd like to see if this trend continues...
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