NIH Xtandi/Prostvac trial screening

As suggested by Wampuscat (Marie) and Adjust (Don) I went to NIH for an acceptance screening to be in a trial to compare enzalutamide to enzalutimide with prostvac vaccine. I was accepted into the trial but did not get the vaccine cohort. I will be on the med only. The screen consisted of several scans... CT (chest, abdomen, and pelvis), nuclear bone scan, and PET bone scan as well as extensive blood and urine analysis. I do not think I have had such a thorough evaluation of my status at any time during my treatment.

One thing that has bothered me for some time has been the nagging feeling that my radiation treatment was flawed somehow. After this evaluation I see that it was very successful in eliminating any cancer in my prostate and the two local pelvic lymph nodes that were questionable at diagnosis as that area showed no activity. So, now I know that the genie was already out of the bottle and my original decision was good.

The chest scan confirmed my lung mets and at least one swollen lymp node in that area. Likely spread through my lymphatic system. (my opinion) The lung mets appear to be stable from previous scans and some are necrotic. I am hoping the enzalutamide will help in this area. One of the doctors mentioned that lung mets were fairly rare as a first location.

My bone scans continue to be clear.

I also met with the doctors who are conducting the study and we were all a bit dissappointed when I did not draw the vaccine arm of the study. I was pretty excited by what I heard regarding that potential treatment.

All in all a worthwihile visit and I look forward to participating in the trial. It will be well worth the travel just for the frequency and depth of the analysis. I feel fortunate to be part of this.

Once again, thanks to Marie and Don for thier prompting and contact information about the trial.

Don

ProstVac might have results in as little time as a year from now. Final data collection Dec. 15 and study completion August 16, for phase III.

Hey Don
hope to see you sometime at nih. Just started a second go round of the (amended) trial you are referring to. In one month my psa went from 7.1 to .45. should be lower in March. Will return next on March 10th, for 3 days. Will have my regular appointment as well as some scans (another trial in the immaging department) nih is a great place to be!
Jim
(Marie's hubby)

Houseboy,

Is this it?

https://clinicaltrials.gov/ct2/show/NCT01867333

Houseboy,

I think Jerry's link is the right one. I do not have a link myself as I printed off the documents.

Todd,

You may want to read the trial notes too. I think chemo naive was the only requirement for previous treatment and HRPC with a rising psa.

Don

Don