Weight LOSS after ADT and METS

As I sit here trying to figure out how to lose the 10mpound spare tire I’ve gained around my middle on my 6 month course of Lupron, I’m trying to make sense of this, it seems so counterintuitive. Admittedly, I’m not great at reading and interpreting studies. Maybe I’m missing something. In any case, maybe it’s worthy of discussion....

https://www.ncbi.nlm.nih.gov/pubmed/30701374

”In multivariable analysis, weight loss was associated with increases in risks of metastases (HR 3.13; 95% CI 1.40-6.97), PCSM (HR 4.73; 95% CI 1.59-14.0), and ACM (HR 2.16; 95% CI 1.25-3.74) compared with mild weight gains of ≤ 2.2. “

”CONCLUSIONS:
Our results suggest that weight loss following ADT initiation in men who have undergone RP is a poor prognostic sign. If confirmed in future studies, testing ways to mitigate weight loss post-ADT may be warranted.”

Mr. Ken, you are killing me! Just when I started to think it was great that I was actually losing my 5 - 7 pounds I gained while on ADT, you come out with this study!

I have started to lose about 2 - 3 pounds, and even after reading the study, I still want to get and stay at 160 or so pounds. Bike riding is certainly helping and I still have about 2 months here in Florida. I will definitely make the best of my time here.

I have a great way to lose weight. Move the bathroom scale in front of the bathroom sink so when you're standing you can place your right hand on the sink. Now stand on the scale, place your right hand on the sink and push down on the sink.

I've lost up to 30 pounds with this method...

I wonder if the weight loss is associated with more cancer and loss of appetite with the more severe cases. In the men that gained weight, they had less cancer and were eating more. So rather than losing weight causing the cancer, the cancer causes the loss of weight. Therefore correlation rather than cause.

I remember how my dad hated meal times during the later stages of his prostate cancer. The thought of food made him ill. I remember him telling me after failing to eat, "that will be the last thing I will ever eat." I thought he was exaggerating. He still sounded and looked strong. He was correct though. He died a few days later.

Paul

Geez... I’ve been working hard to lose weight post ADT...and its been working. I’ll keep working at it. We’re all just hoping this turns out. Not something we can control. On we go...

PDL17 said...
the weight loss is associated with more cancer and loss of appetite with the more severe cases. the cancer causes the loss of weight. Therefore correlation rather than cause.

Precisely, Paul. It is known as "cancer cachexia". Many of us here, like you, by the time we've reached the age where PCa becomes common, we've probably watched parents, as well as siblings and close friends "waste away" and die, often from cancer. Malnutrition is common in later stage cancer. So is living living on liquid nutrition and likely forced high calorie diet, as they tend to eat so little.

BTW Ken and others, several of my relatives have had good luck with the Keto diet. None of them are post ADT, but I'm guessing that outside of cachexia, weight loss is weight loss.

Both!

The advanced disease often leads to malnutrition, which causes other health problems. So I suppose one can be in the late stage of cancer, but actually die from the effects of starvation.

"Our results suggest that weight loss following ADT initiation in men who have undergone RP is a poor prognostic sign"

what am I missing? it's very unusual to lose weight after "ADT initiation" (I gained like 25 lbs) so I can see that as a red flag. it's very rare to see someone lose weight while chemically castrated. I lost all that weight and more once my T returned, and quickly via diet and exercise.