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Xtandi failing so I'm in the ARV110 trial

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Posted 7/22/2019 3:27 PM (GMT -5)
After a nearly five year run on Zytiga, then Xtandi, my PSA is rising. I learned about a phase one trial with a drug from Arvinas called ARV-110. My local onco and my MDA onco agreed that this is an opportune time to try this new drug. My PSA, around the 6 level was not sky high. So I was referred to the Sarah Cannon Center in Nashville, was screened and accepted. I am on day six of dosing. It is two tabs by mouth per day. No SE yet. I had to do a two week wash out meaning I stopped taking Xtandi. PSA jumped to 8. As I understand, instead of blocking androgen like Zytiga and Xtandi, this drug targets the receptors and degrades them. So here we go. Let's hope this works.
Posted 7/22/2019 4:26 PM (GMT -5)
I have done a little reading on this new drug. Iā€™m hopeful it becomes another effective means of managing PCa. Thanks for posting, please keep us updated, and good luck!
Posted 7/22/2019 8:19 PM (GMT -5)
Good luck Faustman, really hoping this works for you, as mattam said, please try to keep us in the loop if you can.
šŸ™šŸ»
Posted 7/22/2019 11:35 PM (GMT -5)
Here's hoping that works for you. I really admire guys who are willing to do these trials.

Keep us updated.

Andrew
Posted 7/23/2019 10:43 AM (GMT -5)
Thanks for posting and thanks for participating in the trial. Good luck and keep us posted.
Posted 7/28/2019 10:51 AM (GMT -5)
Update1: I am 12 days into the trial dosing with no noticeable side effects. I go back to clinic on Fridays for labs,ekg. The first post-dosing PSA will be Day 1 of the second 28 day cycle which is August 16 I think. Starting with the second cycle, I go back for labs every other week. Scans will not be done until October or November.

The Sarah Cannon Center is in Nashville near Vanderbilt U. I was thinking about catching a football game. Ticket prices are outrageous for SEC games, and I wanted a game after the cooler weather arrives or a night game. Oh, they told me to avoid sunlight while on this trial medication. So I will drop the football game idea.
Posted 7/28/2019 12:54 PM (GMT -5)
Thanks for the update. I take great interest in the trial. Please keep them coming. Good thing you're not in Tucson for the sun. The heat and monsoon humidity have been effing miserable. Seems a little hotter every year.

Good luck!
Posted 7/28/2019 1:08 PM (GMT -5)
Phase one trials usually involve experimenting to find the maximum safe dose and evaluate the overall safety of the drug..Any improvement in the participants condition is an added bonus at this stage of testing, right ?? In any case, best of luck to you...
Posted 7/28/2019 2:26 PM (GMT -5)
Fairwind- yes Phase 1 is for safety and tolerance. This is a dose escalation trial. Worked well against PCa in mice. I am hopeful it works for all participants.
Posted 7/29/2019 9:34 AM (GMT -5)
Thanks for the update Faustman. I am right behind you and will eagerly watch for your updates. In April I had to discontinue Xtandi due to the side effects. My PSA on July 26 was .003, down from .004. How often are you traveling to Nashville? Email me if you would rather answer questions that route.
Michael
Posted 7/29/2019 10:54 AM (GMT -5)
You've got lots of people rooting for you, Faustman. Best of luck with what you're going through!
Posted 7/31/2019 1:53 PM (GMT -5)
Your trial sounds interesting!!! Sure hope it works for you!!! Are they just working on prostate cancer or are there multiple cancers they are testing it on? My husband did a phase 1 trial earlier this year, he was the only one with prostate cancer, and it didn't help him, which was disappointing. It was an immunotherapy type drug. Will be looking forward to hearing how it works!!!
Posted 8/1/2019 1:03 PM (GMT -5)

Sending you 100% of my support and best wishes, as you begin this new trial.

I feel a debt of gratitude to everyone who tries a new approach or enlists in a trial --- it's how advances are made, for the present and future.

Handshake and best wishes,
CYCLONE ~ Iowa State University
Posted 10/26/2019 7:31 PM (GMT -5)
Update: I'm still in the trial and will complete my second eight week period in early November. They will do scans then to see what's going on. I'm a little reluctant to say much about the trial because it's drug development and share prices are impacted by any and all news of the trial. I will say that they have a similar protein degradation trial for breast cancer. But I wanted to report that I'm still participating in the trial and intend to continue. Best to all.
Posted 10/26/2019 7:40 PM (GMT -5)
Thanks for the update. Good luck!
Posted 6/8/2020 3:10 PM (GMT -5)

Hello Faustmann,

We last heard from you last summer and into the fall, after you had been on both XTANDI and ZYTIGA, then experienced a rising trend in PSA scores.

You had gotten enrolled in a new trial with a promising new medication known as ARV-110. I was really thankful when you reported minimal side effects.

Summer-like weather is here ~~~ some time has gone by ~~~ hoping to have an update from you, when time allows.

Hoping, above all else, that this finds you doing well ~~~ and I hope the new trial and ARV-110 medication have been helpful and beneficial to you, Faustmann.

Respect & gratitude to everyone who steps forward, and enlists in new trials ~~~ a note of THANKS sent to you, Faustmann, and hoping the trial has paid dividends for you.

Sent with my best,
CYCLONE ~~~ # Iowa State University
Posted 6/9/2020 7:41 PM (GMT -5)
Yes, this drug (ARV-110) represents a 'first in class' and a positive progress report would be great.
The company that is developing the drug will present at the next ASCO meeting. Here is a link to a very recent press release from them:
https://www.globenewswire.com/news-release/2020/05/13/2033092/0/en/arvinas-announces-updated-phase-1-data-demonstrating-clinical-activity-of-protac-protein-degrader-arv-110-in-patients-with-refractory-prostate-cancer.html
As mentioned, this trial is a dose escalation study.

Post Edited (Sr Sailor) : 6/9/2020 6:44:09 PM (GMT-6)

Posted 6/14/2020 7:42 AM (GMT -5)

Sr. Sailor ā€¢ā€¢ā€¢

I appreciate the link to this study update on trials for the ARV-110 medication.

We need more weapons in the armory for our comrades in need, after they have taken XTANDI & ZYTIGA & undergone chemotherapy.

Thankful to researchers and all trial participants, everywhere ā€¢ā€¢ā€¢ in the search to find those much-needed "next step" medications & treatments that will expand the treatment landscape.

We've got fellows here who have signed up for trials, past & present. I'm sincerely thankful to ALL of them. It's the way FORWARD.

Thanks for the link update, Sr. Sailor ~~~ it's good to stay informed on potential new developments.

CYCLONE ā€¢ā€¢ā€¢ # Iowa State University
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