Radio Sensitizers and stuff...

Have RT coming up and am trying to investigate radio sensitizers.

I don't want to take anything that is still under controversy. Looking for things that basically could/will help, but pretty much won't do any harm in making the RT less effective.

In my research, it seems that in the past, people were advised not to take anything that may be an anti-oxident, as the PCa is killed by oxidation (or direct oxidation is one of the modes that kills the PCa? ).

When I pull up the current literature, I am seeing that several of the supplements are getting reviews that are pretty much that it's a positive thing to do.

The three that I have found so far that seem to have positive reviews are

-Curcumin

-Melatonin

-Resveratrol

What do you think about these three? Any other to add to the list?

As Mattam wrote, leave it to your radiation specialists.
More in general, the idea of radiation therapy is to create radicals. These unstable particles have 'extra' energy that they want to dissipate. Breaking up DNA (in cells) will do just that. Normal cells can repair much of the damage, but cancer cells are less able to do that.
This is greatly oversimplified, but not incorrect, I believe.

Moved this over from the O therapy thread…

Groundhogy, Your question led to some good reading.

Good 2021 article summarizing the research on Exercise modulation of tumour perfusion and hypoxia to improve radiotherapy response in prostate cancer

https://www.nature.com/articles/s41391-020-0245-z

This recent (2022) article argues more specifically that exercise can help make the prostate cancer less hypoxia and therefore more sensitive to RT.

https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-022-00436-9

Key Points
- A lack of oxygen to the tumour (hypoxia) impairs radiotherapy treatment efficacy.

- Exercise may beneficially alter components of the TME (tumor micro environment) and act as a sensitiser for treatment.

- Reactive oxygen species generated by exercise and redox-sensitive mechanisms within the tumour, alongside a host of other exercise-induced mechanisms, may prove pivotal in facilitating the treatment effects.

The hospital I go to is actually prepping a clinical trial to mix exercise and RT, but not to improve RT efficacy, but to improve RT tolerance and QOL.

https://clinicaltrials.gov/ct2/show/NCT04556045

Yes, this goes along with the oxygen post.
Today I moved my Planet Fitness account from Lancaster to Reisterstown road, Balto. Very close to the radiation table.
Plan is to go to gym an hour or so early, and then the Rad table.

I think just the rapid pumping and mixing around of blood and stuff from exersize may move fluids in and out of the tumor. Maybe the tumor oxygen level will rise a bit and maybe hydrate the tumor a bit, and maybe make it less acidic?

Well, if you code on a treadmill, you just drop on the spot...

Yes, it's a close call..
Dropping all at once right on the spot is looking pretty attractive.