Actinium 225 PSMA -A new Frontier

After six treatments of LU-177 and six more treatments of Pluvicto, My PSA has been rising quicky, now to around 137. As some of you will recall from my previous posts, I did LU-177 treatment #1 August 2021 when PSA was 65. PSA dropped to 0.65 before it began going up. In May 2023, with PSA around 300, I stated six more treatments of LU-177/Pluvicto. In January 2024 PSA dropped to 5.91. 5 months later and we’re at 137.

Actinium (225Ac-PSMA) is the next new PC breakthrough treatment, and in limited studies showing dramatic reductions in PSA and disease. I have just today been approved for a very limited Actinium trial. I want to tell anyone who has had at least a couple cycles of LU-177/Pluvicto, that successfully lowered disease and PSA, and is now facing greater uptick in PSA, you may be eligible for this trial.

Its National Clinical Trial number is NCT-0640233. There are only about 60 spots open for this, so if this is something you or another brother should know about this, please look it up.

I will, as always, keep everyone informed on my progress. My blessings continue. Here’s hoping yours do, too.

Steve

Steve,
Hard to believe it has been just about 3 years since you started navigating these treatments. I can’t help but think that’s at least 3 extra years added onto life, not to mention what may be gained with Actinium. I haven’t researched it yet, but I’m thinking Actinium probably packs a more powerful radiation punch than Pluvicto.

Steve, you’re out there with a machete hacking a trail for the rest of us. Thank you Sir.

Best wishes, Steve. Sure hope you have the same response that you had with Pluvicto, but that it is longer lasting. You are making the way for others not far behind you, including my husband. We are encouraged by your determination and bravery. Denny just had his 7th Pluvicto infusion last week and we are hopeful for good results (there are two more infusions planned). Please let us know how the Actinium 225 goes.

Trust me when I say, Steve55777, all of us are rallied around you.

I hope this new treatment packs a mighty wallop against enemy cells.

We owe you a debt of gratitude for forging ahead into "unmapped and uncharted territory."

The treatments which you have pursued with PLUVICTO are going to become important new weapons in the fight.

Here's to grand success with this new treatment.

I will be keeping you close in my thoughts. I will watch for your posts and updates.

May your courage remain undaunted, as ever before!

Handshake, camaraderie, supportive thoughts, and fellowship ~
CYCLONE ~ # Iowa State University

This is Janice, Steve55777's wife. Sadly, days before Steve was scheduled for his (3rd round of Lu-177 or Pluvicto) entitled Actinium 225 a clinical trial, he had a severe stroke on July 13. For a few days, following surgery, we thought he was becoming the leader of stroke recovery but no, things shifted, and hospice was the only choice. Five weeks later, August 16, he took his peaceful last breath. He had a full life filled with gratefulness and was a leader in all he did, including his cancer...this blog. His newest passion, singing with an innate ability for beautiful harmony was realized in his last few years. He sang his heart out the day before little strokes began. So incredibly grateful he didn't experience cancer pain, and only a few weeks of on and off frustration of not being able to speak or move his right side.
You, his friends, on this site meant so much to him, encouraging him and allowing him to help others with his experiences, knowledge and research. Thank you. He did his part once cancer hit, being vegan, no intoxicants along with regular exercise. But his consistent positive and grateful attitude was by far, the "medicine" that helped him the most. So, stay grateful and positive as you move through your prostate cancer. Love, Janice

Janice, your post is a wonderful tribute to Steve and the way he lived his life. I am so sorry for your loss. May Steve rest in peace