Cancer free with PNI

Whatprostate318

New Member

Joined : Apr 2024

Posts : 8

Posted 6/28/2024 12:31 PM (GMT -5)

I am curious to know if there are any men who had RP and remained cancer free afterwards who had perineural invasion on their post surgical pathology report.

Mumbo

Veteran Member

Joined : Nov 2018

Posts : 2849

Posted 6/28/2024 1:53 PM (GMT -5)

How long? Is 2018 RALP long enough?

I never found any conclusive evidence that perineural invasion (PNI) was a major indicator of much. It seemed that the discussion centers around does PNI indicate higher risk or does higher risk indicate PNI? chicken or the egg? There have been some studies that indicate PNI may increase risk of recurrence but after adjustment become inconclusive. Since most men with "real" PCa will have PNI, it would seem pretty bleak if PNI was a major indicator which is not the case.

Whatprostate318

New Member

Joined : Apr 2024

Posts : 8

Posted 6/28/2024 2:00 PM (GMT -5)

Thank you for your response.

Sr Sailor

Veteran Member

Joined : Sep 2015

Posts : 1572

Posted 6/28/2024 3:23 PM (GMT -5)

That's my impression as well.
A more scholarly examination can be found here:
https://www.auajournals.org/doi/10.1097/ju.0000000000002609.01

Post Edited (Sr Sailor) : 6/28/2024 1:05:22 PM (GMT-8)

JNF

Veteran Member

Joined : Dec 2010

Posts : 6097

Posted 6/29/2024 5:05 PM (GMT -5)

I had PNI in three cores. No RP, but pretty complete ablation by radiotherapy. Still no cancer after 13 &1/2 years.

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