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Testosterone Level after HT

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Posted 11/27/2024 11:12 AM (GMT -5)
My husband, age 73, is recovering well from his RT/HT. However, we are puzzled by the lab test done yesterday. His testosterone level dropped a little.

Diagnosed in June 2022 with G8, PSA 6.59
TURP: Sept/Oct 2022 (preparing for RT)
26 RT (EBRT): June/July 2023
18 month HT: Sept 2022 thru March 2024 (Lupron shot once every 3 months and Abiraterone 1000mg daily)

PSA undetectable since Dec/2022 (4 months after HT) till now

Testosterone base line before HT/RT = 380 ng/dL

During the entire HT period = <1ng/dL

Testosterone post HT:
7/23/2024 (4 months post HT) = 24ng/dL
10/06/2024 (6.5 months post HT) = 64
11/26/2024 (8 months post HT) = 55

Questions:
1) Testosterone is lower than 1.5 months ago (from 64 to 55). Is it common that the level is not steadily climbing back?
2) For his age (73), how much can we expect the testosterone to recover and how long will it take ?

Your real life experiences would be highly appreciated. Thank you.
Posted 11/27/2024 11:46 AM (GMT -5)
I think there is a correlation to how long you're on ADT to how long until your T recovers. On 2 years= approximately 2 years to recovery. The older you are the more time you can add. I've been off all treatment for almost 2.5 years and still have not recovered T. The best thing I read in your post was "undetectable". Best wishes for continued good health.
Posted 11/27/2024 11:55 AM (GMT -5)
You also may want to research TRT(testosterone replacement therapy) & discuss with his Docs. The leading Dr. is interviewed here.

https://grandroundsinurology.com/interviews-with-icons-abraham-morgentaler-md-facs-and-testosterone-therapy-in-clinical-medicine/
Posted 11/27/2024 1:29 PM (GMT -5)
I recall my T being a little low years ago and doctor scheduled retest in morning, all ok. Basically, he told me that T fluctuates a lot during the day and night. Can be as much as 30%+ in younger men and is less with older men (10%?).
Posted 11/29/2024 11:32 AM (GMT -5)
Opioid medication over many years has destroyed my natural production hence my need for TRT
Throw in Pca and darn it's not been easy getting it but I have throughout my treatment and beyond.

I have been tested at 25 which is very low.
The main reason I am on TRT is emotional. I welcome any other benefits but without TRT, I am a basket case.

Glen
Posted 11/30/2024 7:59 AM (GMT -5)
4 years after the last round of leuprolide & enzalutamide chemotherapy my testosterone has hit 136. Has been dropping since 'recovering' to 330, 3 years after the first round of leuprolide chemo. I remain grateful that my marriage is about much more than sex as I cannot do that and am not interested. 'T replacement' would be very frustrating.
Posted 12/5/2024 8:13 PM (GMT -5)
Summer, while the drop from 64 to 55 may seem important, I don't think it is. T levels can vary by a lot, even depending on the time of day, lab used, activities the previous day (exercise). So I wouldn't sweat one reading. It will take time to come back. And the fact that your husband was at the low end of normal in the 300's baseline, might make it take longer. I was also in the 300's and after 6 months of HT it took about a year IIRC correctly to return to baseline of 322. Since then it has gone up and down like a yoyo. My most recent was last month at 265 . If he feels ok, I wouldn't be concerned, just be patient
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